Improve Survival Prediction Using Principal Components of Gene Expression Data  

作　　者：Yi-Jing Shen Shu-Guang Huang 

机构地区：[1]Department of Statistics, University of California, Los Angeles, CA 90095-1554, USA [2]Statistics and Information Science, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA.

出　　处：《Genomics, Proteomics & Bioinformatics》2006年第2期110-119,共10页基因组蛋白质组与生物信息学报（英文版）

摘　　要：The purpose of many microarray studies is to find the association between gene expression and sample characteristics such as treatment type or sample phenotype. There has been a surge of efforts developing different methods for delineating the association. Aside from the high dimensionality of microarray data, one well recognized challenge is the fact that genes could be complicatedly inter-related, thus making many statistical methods inappropriate to use directly on the expression data. Multivariate methods such as principal component analysis （PCA） and clustering are often used as a part of the effort to capture the gene correlation, and the derived components or clusters are used to describe the association between gene expression and sample phenotype. We propose a method for patient population dichotomization using maximally selected test statistics in combination with the PCA method, which shows favorable results. The proposed method is compared with a currently well-recognized method.The purpose of many microarray studies is to find the association between gene expression and sample characteristics such as treatment type or sample phenotype. There has been a surge of efforts developing different methods for delineating the association. Aside from the high dimensionality of microarray data, one well recognized challenge is the fact that genes could be complicatedly inter-related, thus making many statistical methods inappropriate to use directly on the expression data. Multivariate methods such as principal component analysis （PCA） and clustering are often used as a part of the effort to capture the gene correlation, and the derived components or clusters are used to describe the association between gene expression and sample phenotype. We propose a method for patient population dichotomization using maximally selected test statistics in combination with the PCA method, which shows favorable results. The proposed method is compared with a currently well-recognized method.

关 键 词：MICROARRAY principal component analysis SURVIVAL 

分 类 号：Q-3[生物学]