视野丧失模式与视神经纤维层厚度测量之间的关系  

Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements

作　　者：Hoffmann E.M. Medeiros F.A. Sample P.A. R.N. Weinreb 杨秀梅 

机构地区：[1]Hamilton Glaucoma Center,Department of Ophthalmology,University of California,San Diego,9500 Gilman Drive,San Diego,CA 92093-0946,United States Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期5-6,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements. DESIGN: Observational cross-sectional study. METHODS: One hundred twenty-one glaucoma patients and 65 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were included. All glaucoma patients had repeatable abnormal VFs and scanning laser polarimetry (SLP) RNFL thickness measurements. RNFL measurements were obtained from 16 equal parapapillary sectors. Patterns of VF loss were classified as arcuate,partial arcuate,nasal step,or paracentral in each VF hemifield. Logistic regression analysis was performed to determine which RNFL sectors were associated with each VF pattern. The ability of SLP to discriminate between eyes with different VF patterns and healthy eyes using receiver operating characteristic (ROC) curve analyses also was investigated. RESULTS: VF patterns in the superior hemifield were significantly associated with RNFL sectors in the temporal inferior hemiretina (P < .05). ROC curve areas for discrimination between eyes with differentVF patterns and healthy eyes ranged from 0.85 to 0.95. VF patterns in the inferior hemifield were most strongly associated with temporal superior RNFL sectors (P < .05). ROC curve areas for discrimination between different VF patterns and healthy eyes ranged from 0.73 to 0.98. SLP could discriminate between apparently unaffected VF hemifields in glaucoma eyes and VF hemifields in healthy eyes. CONCLUSIONS: Parapapillary RNFL thickness was topographically related to patterns of VF loss. SLP can differentiate between apparently unaffected VF hemifields in glaucoma eyes and normal VF hemifields in healthy eyes.PURPOSE： To investigate the association between patterns of visual field （VF） loss and retinal nerve fiber layer （RNFL） thickness measurements. DESIGN： Observational cross-sectional study. METHODS： One hundred twenty-one glaucoma patients and 65 healthy subjects from the Diagnostic Innovations in Glaucoma Study （DIGS） were included. All glaucoma patients had repeatable abnormal VFs and scanning laser polarimetry （SLP） RNFL thickness measurements. RNFL measurements were obtained from 16 equal parapapillary sectors. Patterns of VF loss were classified as arcuate, partial arcuate, nasal step, or paracentral in each VF hemifield. Logistic regression analysis was performed to determine which RNFL sectors were associated with each VF pattern. The ability of SLP to discriminate between eyes with different VF patterns and healthy eyes using receiver operating characteristic （ROC） curve analyses also was investigated. RESULTS： VF patterns in the superior hemifield were significantly associated with RNFL sectors in the temporal inferior hemiretina （P 〈 . 05） . ROC curve areas for discrimination between eyes with differentVF patterns and healthy eyes ranged from 0. 85 to 0. 95. VF patterns in the inferior hemifield were most strongly associated with temporal superior RNFL sectors （P 〈. 05） . ROC curve areas for discrimination between different VF patterns and healthy eyes ranged from 0. 73 to 0. 98. SLP could discriminate between apparently unaffected VF hemifields in glaucoma eyes and VF hemifields in healthy eyes.

关 键 词：视神经纤维层 厚度测量 受试者操作特征曲线 Logistic回归分析 青光眼患者 NFL厚度 RNFL 横断面研究 半视野 健康眼 

分 类 号：R775[医药卫生—眼科]