异波帕明滴眼对玻璃体视网膜手术、葡萄膜炎和眼部穿通伤引起的慢性低眼压的疗效研究  

Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery,uveitis,or penetrating trauma

作　　者：Ugahary L. C. Ganteris E. Veckeneer M. 安胜(译) 

机构地区：[1]不详 [2]Rotterdam Eye Hospital, PO Box 70030, 3000 LM Rotterdam, Netherlands

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期13-13,共1页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery,uveitis,or penetrating trauma. DESIGN: A prospective randomized,double-blind,placebo controlled,crossover study. METHODS: In ten patients with ocular hypotony,an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days,2 weeks apart. RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes .010) compared with placebo. CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.PURPOSE： To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma. DESIGN： A prospective randomized, double-blind, placebo controlled, crossover study. METHODS： In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart. RESULTS： The mean lOP integral after administration of ibopamine was 2. 4 mm Hg higher （95% CI for median difference in AUC over 480 minutes . 010） compared with placebo. CONCLUSIONS： The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

关 键 词：玻璃体视网膜手术 慢性低眼压 异波帕明 滴眼治疗 葡萄膜炎 穿通伤 疗效研究 安慰剂对照 眼部 压平眼压计 

分 类 号：R779.6[医药卫生—眼科] R779.1[医药卫生—临床医学]