维替泊芬光动力治疗后出现背痛  

Back pain after photodynamic therapy with verteporfin

作　　者：Pece A. Vadalà M. Manzi R. Calori G. 邢咏新 

机构地区：[1]Dept. of Ophthalmology,Melegnano Hospital,Via Pandina 1,20077,Vizzolo Predabissi,Milano,Italy Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期17-18,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: To report the incidence of back pain after photodynamic therapy,which suggests methods for prevention that are related to its pathogenesis. DESIGN: Retrospective case series. METHODS:We retrospectively observed 548 patients who had undergone photodynamic therapy with verteporfin. RESULTS: Of 548 patients at the first treatment,14 patients (2.6% ) experienced pain during the infusion. Eleven patients were being treated for age-related macular degeneration; their mean age was 81 years,which significantly differed from the mean age of the overall age-related macular degeneration group (P=.003). The pain was mild in eight patients,moderate in four patients,and severe in two patients,with dyspnea and precordial pain. Five of the 14 patients had further courses of photodynamic therapy. After being treated prophylactically 60 minutes before photodynamic therapy,only one patient reported further mild pain. CONCLUSIONS: The biologicmechanisms of back pain may involve a high level of circulating thromboxanes that are induced by the liposomal composition of verteporfin. Prevention may include hydration,nonsteroidal anti-inflammatory drugs,and halving the infusion rate.PURPOSE： To report the incidence of back pain after photodynamic therapy, which suggests methods for prevention that are related to its pathogenesis. DESIGN： Retrospective case series. METHODS： We retrospectively observed 548 patients who had undergone photodynamic therapy with verteporfin. RESULTS： Of 548 patients at the first treatment, 14 patients （2.6%） experienced pain during the infusion. Eleven patients were being treated for age-related macular degeneration; their mean age was 81 years, which significantly differed from the mean age of the overall age-related macular degeneration group （P =. 003）. The pain was mild in eight patients, moderate in four patients, and severe in two patients, with dyspnea and precordial pain. Five of the 14 patients had further courses of photodynamic therapy. After being treated prophylactically 60 minutes before photodynamic therapy, only one patient reported further mild pain. CONCLUSIONS： The biologicmechanisms of back pain may involve a high level of circulating thromboxanes that are induced by the liposomal composition of verteporfin. Prevention may include hydration, nonsteroidal anti-inflammatory drugs, and halving the infusion rate.

关 键 词：光动力治疗 维替泊芬 后背痛 治疗后 年龄相关性黄斑病变 心前区疼痛 非甾体类消炎药物 回顾性观察 出现 药物输注速度 

分 类 号：R77[医药卫生—眼科]