后部葡萄膜黑色素瘤^(125)I板放射治疗后的脂质渗出  

Lipid exudation following plaque radiotherapy for posterior uveal melanoma

作　　者：Mills M. D. Harbour J. W. 王大江(译) 

机构地区：[1]不详 [2]Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, United States

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期18-18,共1页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma. DESIGN: Retrospective interventional case series. METHODS: Records of 139 consecutive uveal melanoma patients treated with I-125 plaque radiotherapy were reviewed. Lipid exudation was the major outcome measured. RESULTS: Lipid exudation was detected in 19 patients (13.7% ). Mean time from plaque therapy to lipid exudation was 10 months (range,3-23 months). Lipid exudation was associated with younger patient age (P=.0002),increased low-density lipoprotein (P=.004),decreased highdensity lipoprotein (P=.026),increased tumor thickness (P=.024),and exudative retinal detachment (P=.016). Patients with lipid exudation had worse visual outcome (P < .0001) and increased neovascular glaucoma (P=.01). CONCLUSIONS: Lipid exudation after plaque radiotherapy for uveal melanoma is associated with poor ocular outcome. Factors associated with this lipid exudation are distinct from those associated with radiation retinopathy,and they may suggest interventions to combat this complication.PURPOSE： To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma. DESIGN： Retrospective interventional case series. METHODS： Records of 139 consecutive uveal melanoma patients treated with I - 125 plaque radiotherapy were reviewed. Lipid exudation was the major outcome measured. RESULTS： Lipid exudation was detected in 19 patients （13.7%） . Mean time from plaque therapy to lipid exudation was 10 months （range, 3 -23 months） . Lipid exudation was associated with younger patient age （P= . 0002）, increased low-density lipoprotein （P =. 004）, decreased highdensity lipoprotein （P =. 026）, increased tumor thickness （P=. 024）, and exudative retinal de- tachment （P =. 016） . Patients with lipid exudation had worse visual outcome （P 〈 . 0001） and increased neovascular glaucoma （P =. 01）. CONCLUSIONS： Lipid exudation after plaque radiotherapy for uveal melanoma is associated with poor ocular outcome. Factors associated with this lipid exudation are distinct from those associated with radiation retinopathy, and they may suggest interventions to combat this complication.

关 键 词：渗出性视网膜脱离 葡萄膜黑色素瘤 放射治疗后 ^125I 脂质 新生血管性青光眼 患者年龄 低密度脂蛋白 高密度脂蛋白 视网膜病变 

分 类 号：R774.12[医药卫生—眼科] R739.7[医药卫生—临床医学]