青光眼视神经病变而自动视野计检查正常的患者身心和结构损害的检测  

Detection of psychophysical and structural injury in eyes with glaucomatous optic neuropathy and normal standard automated perimetry

作　　者：Bagga H. Feuer W. J. Greenfield D. S. 王大江(译) 

机构地区：[1]不详 [2]BascomPalmer Eye Institute, 7108 Fairway Dr, Palm Beach Gardens, FL 33418, United States

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期19-20,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Objective: To compare the prevalence of structural and psychophysical abnormalities in normal eyes and eyes with glaucomatous optic neuropathy (GON) and normal standard automated perimetry (SAP). Methods: Complete examination,SAP,short-wavelength automated perimetry (SWAP),frequency doubling technology (FDT),scanning laser polarimetry (GDx-VCC),and optical coherence tomography (OCT) of the peripapillary retinal nerve fiber layer (RNFL),optic disc,and macula were performed. Glaucomatous optic neuropathy was defined as cup-disc asymmetry between fellow eyes of greater than 0.2,rim thinning,notching,excavation,or RNFL defect. All eyes had normal SAP. Abnormal measurements on OCT,GDx-VCC,SWAP,and FDT were defined as those outside 95% normal limits. Eyes were stratified into 3 groups based on the OCT-generated vertical cup-disc ratio: mild,moderate,and advanced cupping (cup-disc ratio of < 0.4,0.4-0.7,and >0.7,respectively). Receiver operating characteristic curves were developed to assess sensitivity and specificity of structural and functional assessments. Results: Forty-seven eyes of 47patients (25 with GON and 22 normal) were enrolled (mean± SD age,58± 16 years; range,25-83 years). Compared with normal eyes,eyes with GON had significantly worse mean deviation and pattern standard deviation by means of SWAP and FDT (P=.02-.05); OCT-derived mean and superior and inferior RNFL thickness (P=.008,< .001,and .05,respectively); mean macular thickness (P=.01),rim volume,rim area,cup-disc ratio,and cup area (all P< .001); and GDx-VCC nerve fiber indicator and inferior average (P=.03). There was a significantly (P=.008,.002,.003,and .01,respectively) greater prevalence of abnormalities identified by SWAP,FDT,OCT and GDx-VCC in eyes with advanced cupping (43% ,43% ,57% ,and 57% ,respectively) compared with mild cupping (0% ) and moderate cupping (9% ,5% ,19% ,and 33% ,respectively). Conclusions: Eyes with GON and normal results of SAP have significantly greater structural and psychophysical abnormalities than do normal eyeObjective： To compare the prevalence of structural and psychophysical abnormalities in normal eyes and eyes with glaucomatous optic neuropathy （GON） and normal standard automated perimetry （SAP） . Methods： Complete examination, SAP, short-wavelength automated perimetry （SWAP）, frequency doubling technology （FDT）, scanning laser polarimetry （GDx-VCC）, and optical coherence tomography （OCT） of the peripapillary retinal nerve fiber layer （RNFL）, optic disc, and macula were performed. Glaucomatous optic neuropathy was defined as cup-disc asymmetry between fellow eyes of greater than O. 2, tim thinning, notching, excavation, or RNFL defect. All eyes had normal SAP. Abnormal measurements on OCT, GDx-VCC, SWAP, and FDT were defined as those outside 95% normal limits. Eyes were stratified into 3 groups based on the OCT-generated vertical cup-disc ratio： mild,

关 键 词：青光眼性视神经病变 自动视野检查 自动视野计 结构损害 患者 受试者操作特征曲线 视网膜神经纤维层 视乳头周围 检测 平均年龄 

分 类 号：R774.6[医药卫生—眼科] R776.1[医药卫生—临床医学]