吲哚青绿辅助下玻璃体切除术治疗特发性黄斑裂孔后视网膜神经纤维层的分析研究  

Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes

作　　者：Yamashita T. Uemura A. Kita H. Sakamoto T. 安胜(译) 

机构地区：[1]不详 [2]Department of Ophthalmology, Kagoshima City Hospital, 20- 17 Kajiya-cho, Kagoshima-shi 892 -8580, Japan

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期51-52,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Purpose: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography (OCT) and to investigate the relationship between postoperative VF defects and RNFL damage. Design: Retrospective interventional case series. Participants: Thirty-four eyes of 32 patients with idiopathic macular holes that underwent vitrectomy between January 2001 and March 2003 were included in this study. Eyes were divided into 3 groups according to the occurrence of postoperative VF defects and the use of indocyanine green for internal limiting membrane peeling during surgery: 11 eyes with VF defects after indocyanine green-assisted vitrectomy (group 1),9 eyes without VF defects despite the use of indocyanine green (group 2),and 14 eyes without VF defects that underwent vitrectomy without indocyanine green (group 3). Methods: Retinal nerve fiber layer thickness in each of 4 quadrants (superior,inferior,nasal,temporal)was measured with OCT. Main OutcomeMeasure: Retinal nerve fiber layer thickness around the optic disc. Results: The mean RNFL thickness in 3 of 4 quadrants (superior,nasal,inferior) in group 1 was significantly less than that in the corresponding quadrant in groups 2 and 3 (P < 0.01). In the temporal quadrant,there was a significant difference between groups 1 and 3 (P=0.02),but not between groups 1 and 2. The RNFL thickness in group 1 was significantly less in 3 quadrants in operated eyes than in fellow eyes (P< 0.05). Conclusions: The RNFL thickness was reduced in eyes with VF defects after indocyanine green-assisted vitrectomy for macular holes,suggesting that the postoperativeVF defectsmay have been caused by RNFL damage relating to the use of indocyanine green.Purpose： To analyze retinal nerve fiber layer （RNFL） thickness in eyes with or without visual field （VF） defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography （OCT） and to investigate the relationship between postoperative VF defects and RNFL damage. Design： Retrospective interventional case series. Participants： Thirty-four eyes of 32 patients with idiopathic macular holes that underwent vitrectomy between January 2001 and March 2003 were included in this study. Eyes were divided into 3 groups according to the occurrence of postoperative VF defects and the use of indocyanine green for internal limiting membrane peeling during surgery： 11 eyes with VF defects after indocyanine green-assisted vitrectomy （group 1）, 9 eyes without VF defects despite the use of indocyanine green （group 2）, and 14 eyes without VF defects that underwent vitrectomy without indocyanine green （group 3）. Methods： Retinal nerve fiber layer thickness in each of 4 quadrants （superior, inferior, nasal, temporal） was measured with OCT. Main OutcomeMeasure： Retinal nerve fiber layer thickness around the optic disc. Results： The mean RNFL thickness in 3 of 4 quadrants （superior, nasal, inferior） in group 1 was significantly less than that in the corresponding quadrant in groups 2 and 3 （P 〈 0.01 ）. In the temporal quadrant, there was a significant difference between groups 1 and 3 （P =0.02）, but not between groups 1 and 2. The RNFL thickness in group 1 was significantly less in 3 quadrants in operated eyes than in fellow eyes （P 〈 0.05）.

关 键 词：视网膜神经纤维层厚度 特发性黄斑裂孔 玻璃体切除术 吲哚青绿 治疗 NFL厚度 视野缺损 RNFL 内界膜剥离 视乳头周围 

分 类 号：R779.63[医药卫生—眼科] R774.5[医药卫生—临床医学]