光动力疗法治疗脉络膜新生血管后OCT与眼底荧光血管造影的相关性  

Correlation of optical coherence tomography and fundus fluorescein angiography following photodynamic therapy for choroidal neovascular membranes

作　　者：Van DeMoere A. Sandhu S. S. Talks S.J. 安胜(译) 

机构地区：[1]不详 [2]Department of Ophthalmology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, United Kingdom

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期59-60,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Aims: To assess the correlation between optical coherence tomography (OCT) and leakage on fundus fluorescein angiography (FFA) following photodynamic therapy (PDT) with verteporfin for choroidal neovascularisation (CNV). Methods: Retrospective comparative observational case series of patients who were treated with PDT for CNV from one centre. All patients had 3 monthly FFA and OCT following initial PDT to assess if further treatment was required. A pair of FFA and OCT images from the same visit at a random follow up date were taken from each patient’ s series and assessed separately by different observers. The presence of pigment epithelial detachment,subretinal fluid,vitreomacular traction,intraretinal fluid,absence of foveal depression,and the retinal thickness on OCT were correlated with presence of leaks on FFA. Results: A total of 121 eyes of 121 patients were included. The presence of subretinal fluid,gross cystoid macular oedema,sponge-like retinal thickening and retinal thickness of more than 350 μ mon OCT correlated well with leak on FFA (p value < 0.01). The likelihood ratios were 3.0,5.7,2.7,and 3.6,respectively. The presence of a solitary foveal cyst did not correlate well with leaks on FFA. Conclusions: The presence of subretinal fluid,intraretinal fluid in the form of gross cystoid macular oedema,or sponge-like retinal thickening,or a retinal thickness more than 350 μ m correlates with leaks on FFA and so suggests the need for repeat PDT.Aims： To assess the correlation between optical coherence tomography （OCT） and leakage on fundus fluorescein angiography （FFA） following photodynamic therapy （PDT） with verteporfin for choroidal neovascularisation （CNV） . Methods： Retrospective comparative observational case series of patients who were treated with PDT for CNV from one centre. All patients had 3 monthly FFA and OCT following initial PDT to assess if further treatment was required. A pair of FFA and OCT images from the same visit at a random followup date were taken from each patient＇ s series and assessed separately by different observers. The presence of pigment epithelial detachment, subretinal fluid,

关 键 词：眼底荧光血管造影 脉络膜新生血管 光动力治疗 OCT成像 光动力疗法 玻璃体黄斑牵引 视网膜下积液 荧光素渗漏 黄斑囊样水肿 视网膜下液 

分 类 号：R774.5[医药卫生—眼科] R730.5[医药卫生—临床医学]