环氧合酶-2对宫颈癌淋巴管生成及预后的影响  

Effect of cyclooxygenase-2 expression on lymphatic angiogenesis and prognosis in patients with cervical cancer.

作　　者：刘冬菊[1] 娄阁[2] 

机构地区：[1]广州中医药大学第三附属医院妇科,广州510360 [2]哈尔滨医科大学附属肿瘤医院妇科

出　　处：《现代妇产科进展》2006年第6期427-429,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:研究环氧合酶-2(Cox-2)在宫颈癌中的表达并探讨其对淋巴管生成及预后的影响。方法:用免疫组化SP法,分析59例宫颈癌石蜡标本中Cox-2、血管内皮生长因子-C(VEGF-C)及其受体VEGFR-3蛋白表达,并对微淋巴管密度行定量分析。结果:Cox-2蛋白在86.4%(51/59)的病例中呈阳性表达,与VEGF-C表达[66.1%(39/59)]呈显著正相关(r=0.424,P<0.001),且与淋巴结转移、术后生存期缩短有关;在Cox-2表达阳性组淋巴管密度明显高于阴性组(P=0.013)。结论:在宫颈癌中Cox-2可能上调VEGF-C表达,通过促进淋巴管生成与淋巴结转移有关。检测Cox-2可作为预测宫颈癌患者预后的一项指标。To assess the effect of cyclooxygenase-2 （ Cox-2 ） expression on lymphatic angiogenesis and prognosis in uterine cervical cancers. Methods：The expressions of Cox-2, vascular endothelial growth factor-C （VEGF-C） and its receptor VEGFR-3 were identified by immunohistochemically SP method in 59 parafin specimens respectively. Lymphatic vessel density was assessed quantitatively. Results： Cox-2 protein was expressed in 86.4% （51/ 59 ）of patients. The Cox-2 expression was positively related to VEGF-C expression（ r = 0. 424, P = 0.001 ）, and was associated with lymph node metastasis and shortened survival. Lymphatic vessel density was significantly higher in the Cox-2 positive tumor than that in the negative tumor（P =0.013 ）. Conclusions： Cox-2 in cervical cancers may up-regulated the expression of VEGF-C and promotes lymph node metastasis by increasing lym Cox-2 may be a useful biologic marker for predicting prognosis in terine cervix. phangiogenesis. Expression of patients with carcinoma of uterine cervix.

关 键 词：环氧合酶-2 宫颈肿瘤 血管内皮生长因子-C 淋巴管密度 预后 

分 类 号：R737.33[医药卫生—肿瘤]