影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后因素分析  

Factors Related with Therapeutic Effect and Prognosis of Postoperative Radiotherapy for Nasal and Paranasal Sinuses Carcinoma

作　　者：齐高强[1] 王迎选[1] 崔书祥[1] 戴相昆[1] 

机构地区：[1]解放军总医院放疗科,北京市100853

出　　处：《中国康复理论与实践》2006年第6期535-537,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后的因素。方法95例鼻腔副鼻窦恶性肿瘤患者术后接受放疗,生存率计算采用Kaplan-Meier法,生存率差异检验采用Logrank法,多因素分析采用Cox模型。结果本组患者1、3、5、10年总生存率分别为84.2%、50.5%、44.2%和20%。单因素分析显示,性别、年龄、手术方法和肿瘤剂量与生存率无相关性,而临床分期、病理类型与生存率相关。多因素分析显示,临床分期、病理类型是影响预后的独立因素。视力障碍、听力障碍、口干是治疗的主要毒副作用。结论术后放疗能提高鼻腔副鼻窦恶性肿瘤的疗效;临床分期、病理类型是影响放疗预后的重要因素。Objective To investigate the factors related with curative effect and prognosis of postoperative radiotherapy for nasal and paranasal sinuses carcinoma. Methods The data of 95 patients with nasal and paranasal sinuses carcinoma and received postoperative radiotherapy were reviewed retrospectively. Kaplan-Meier method was used to analyze the survival, Logrank test used to compare the differences between different groups. Multivariate analysis was performed by Cox proportional hazard model. Results The overall 1, 3, 5, 10-year survival rates of 95 patients were 84.2%, 50.5%, 44.2% and 200% respectively. Univariate analysis showed that sex, age, operative modality and tumor dose were not related with survival. Histological and clinical stages were related with survival. Multivariate analysis indicated that histological and clinical stages were independent prognostic factors. The follow-up results showed that visual disturbance, xerostomia, dysaudia were the major side effects. Conclusion Postoperative radiotherapy can improve therapeutic effect in the treatment of nasal and paranasal sinuses carcinoma, and histological and clinical stages are the independent prognostic factors effecting prognosis.

关 键 词：鼻腔副鼻窦恶性肿瘤 术后放射治疗 副作用 

分 类 号：R739.62[医药卫生—肿瘤]