PPAR-γ的激动剂吡咯列酮抑制肝癌细胞生长的实验研究  

The effects of Pioglitazone, a Peroxisome proliferator-activated receptor-gamma Ligand on antiproliferation in human hepatocellular carcinoma cell lines

作　　者：丁斌[1] 谢勇[1] 孙辉[2] 黄德强[1] 罗凌玉[1] 陈江[1] 何星星[1] 

机构地区：[1]南昌大学第一附属医院消化研究所,南昌330006 [2]江西省九江市第一人民医院消化科,332000

出　　处：《江西医药》2006年第7期449-451,共3页Jiangxi Medical Journal

摘　　要：目的观察PPAR-γ的激动剂吡咯列酮对肝癌细胞的生长抑制作用。方法采用MTT法研究了不同浓度盐酸吡咯列酮与肝癌细胞株SMMC7721的生长抑制作用,并观察了不同时间对SMMC7721的生长抑制作用。结果吡咯列酮对肝癌细胞有明显抑制作用,随着浓度的升高吡咯列酮对肝癌细胞的生长抑制作用逐渐增强;在高浓度组(20μM以上),在一定的时间范围内(24～120h)随着作用时间延长,抑制作用逐渐增强。结论PPAR-γ的激动剂吡咯列酮可抑制肝癌细胞的生长,并且呈剂量和时间依赖关系。Objective TO study the effect of Pioglitazone, a Ligand of Peroxisome proliferator-aetivated receptor-gamma, for Antiproliferation in hepatocellular carcinoma （HCC） cell lines（SMCC7721）. Methods HCC line SMMC7721 was treated with different concentration of Pioglitazone. Antiproliferation effects was measured by MTT methed at 24, 48 and 72h. Results The growth inhibition effects of Pioglitazone were enhanced along with increase of concentration and time （in groups of eoneentration≥20μM）. Conclusion Pioglitazone can inhibit the growth of HCC cell line in vitro, and the inhibit was dose-depending and time-depending.

关 键 词：盐酸吡咯列酮 过氧化物酶体增生物激活受体-Γ 肝细胞癌 

分 类 号：R73-354[医药卫生—肿瘤]