氯丙咪嗪合并奎硫平治疗强迫症的对照研究  

Comparative study of chlorimipramine with quetiapine in the treatment of obsessive-compulsive disorder

作　　者：刘增训[1] 焦志安[2] 蔡兴芹[2] 

机构地区：[1]山东大学医学院,济南250014 [2]山东省精神卫生中心

出　　处：《山东精神医学》2006年第3期173-174,共2页Shangdong Archives of Psychiatry

摘　　要：目的探讨氯丙咪嗪合并奎硫平治疗强迫症的疗效和副作用。方法60例强迫症患者随机分为氯丙咪嗪合并奎硫平组和氯丙咪嗪组,治疗8周,采用强迫症量表(YBOCS)、副反应量表(TESS)评定疗效和副作用。结果治疗结束时两组YBOCS的评分均降低,而合并奎硫平组降低更明显(P<0.05)。结论奎硫平可以增加氯丙咪嗪治疗强迫症的疗效,副作用较小。Objective To explore the efficacy and side effects of chlorimipramine with quetiapine in the treatment of obsessive-compulsive disorder. Methods A total of 60 patients with obsessive-compulslve disorder were divided into two groups receiving chlorimipramine with quetiapine or chlorimipramine respectively for 8 weeks. The Yale-Brown Obsessive Compulsive Scale （Y-BOCS） and the Treatment Emergent Symptoms Scale （TESS） were used for evaluating efficacy and side effects. Results At the end of treatment, the scores of Y-BOCS in both groups significantly decreased,but the group of chlorimipramine with quetiapine showed more significant. There was no significant difference of side effects in both groups. Conclusion Quetiapine may enforce the efficacy of chlorimipramine in the treatment of obsessive-compulsive disorder,with fewer side effects.

关 键 词：氯丙咪嗪 奎硫平 强迫症 

分 类 号：R749.7[医药卫生—神经病学与精神病学]