Total Synthesis of Phakellistatin 13 by Solution Method  

作　　者：Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan SHENG Can Hui ZHENG Bing YAO 

机构地区：[1]Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433

出　　处：《Chinese Chemical Letters》2006年第8期995-998,共4页中国化学快报（英文版）

摘　　要：Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cyclization were achieved according to our designed method, which was different from the reported process. The spectral data of synthetic product is consisted with literatureal data of natural product. Total synthesis of phakellistatin 13 is a significant achievement to further study of its derivatives and developing novel antitumor drugs.

关 键 词：Phakellistatin 13 solution-phase synthesis cyclopeptide. 

分 类 号：TQ465.6[化学工程—制药化工] R914.5[医药卫生—药物化学]