表观遗传修饰与白血病  

Epigenetic Modification in Human Leukemia——Editorial

作　　者：陈燕[1] 李新刚[1] 

机构地区：[1]华中科技大学同济医学院协和医院血液病研究所,武汉430022

出　　处：《中国实验血液学杂志》2006年第4期635-638,共4页Journal of Experimental Hematology

摘　　要：表观遗传修饰(epigeneticmodification),如DNA甲基化、组蛋白乙酰化和甲基化、RNA相关性沉默与细胞生长、分化、凋亡、转化及肿瘤进展相关基因的转录密切相关。白血病的发生和发展与表观遗传修饰异常直接相关。本文综述细胞周期调节基因甲基化,组蛋白翻译后修饰异常及siRNA对白血病细胞的作用,为白血病治疗提供新策略。Epigenetic modification, which involve DNA methylation, RNA-associated silencing and histone modification, is implicated in cell proliferation,differentiation, survival, apoptosis and malignant transformation. Some leukemogenesis has been shown to be aberrance of epigenetic modification. This paper discussed the potential causes of some of leukemias correlating with the methylation of cell cycle regulation genes, small interference RNA and modification abnormality of histone after translation. The study on epigenetic modification abnormality of leukemia cells provides a new strategy for treatment of leukemia.

关 键 词：表观遗传修饰 白血病 表观遗传学 

分 类 号：R733.7[医药卫生—肿瘤] Q75[医药卫生—临床医学]