微小RNA及其在恶性淋巴增殖性疾病中作用的研究进展  

Progress on the Research of MicroRNA and Its Functions in Lymphoid Malignancies——Review

作　　者：徐卫[1] 李建勇[1] 陆凤翔[1] 

机构地区：[1]南京医科大学第一附属医院血液科,南京210029

出　　处：《中国实验血液学杂志》2006年第4期840-844,共5页Journal of Experimental Hematology

基　　金：江苏省135重点医学人才基金资助项目(编号RC2002044);江苏省六大高峰人才基金资助项目

摘　　要：在动植物基因组中广泛存在一类非编码蛋白的RNA基因,产生长度大约为19-25个核苷酸的RNA,它们被命名为微小RNA(microRNA,miRNA)。这是一类具有调节其他基因表达活性的小RNA。在生物的发育过程中发挥着重要作用。本文对这类基因的特征、生物学功能、产生与作用机制和在恶性淋巴增殖性疾病中作用的研究进展作一综述。Plant and animal genomes contain an abundance of small genes that produce RNAs of about 22 nucleotides in length, which was dubbed as microRNA （miRNA）. These newly found endogenous RNAs may participate in a wide range of genetic regulatory pathways and play an important role in the organism development. This paper reviewed the recent studies and progress on the characteristics, functions and mechanisms of the microRNAs, as well as the advances of research on lymphoid malignancies.

关 键 词：MIRNA 非编码RNA 恶性淋巴增殖性疾病 

分 类 号：R733.1[医药卫生—肿瘤]