非小细胞肺癌相关抗原血清水平与老年重症肺炎预后关系的探讨  

Relationship between non-small-cell lung cancer related antigen CYFRA21-1 serum level and prognosis in elderly patients with severe pneumonia

作　　者：续华[1] 赵锦[1] 李再平[2] 李正春[1] 熊黎[1] 

机构地区：[1]贵州省人民医院干医科,贵阳550002 [2]贵州省人民医院核医学科,贵阳550002

出　　处：《中国医师进修杂志（内科版）》2006年第8期37-38,共2页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨老年重症肺炎(SAP)患者非小细胞肺癌相关抗原(CYFRA21-1)血清水平变化及其对临床转归的影响。方法28例老年SAP患者分为存活组(13例)与死亡组(15例),另选26例老年健康者作为对照组。一旦确诊为SAP,分别于入院当天、治疗后5d及治愈出院或死亡时测血清CYFRA21-1水平,并动态观察神志、血压、SaO2、白蛋白、白细胞计数、PaO2、PaCO2及急性生理和慢性健康状况(APACHEⅡ)评分等指标。结果神志、血压、SaO2、白蛋白、白细胞计数、PaO2、PaCO2及APACHEⅡ评分差异无统计学意义(P>0.05)。治疗第5天血清CYFRA21-1水平死亡组高于存活组(P<0.05),存活组治愈后如仍高,有反复发作肺炎的可能;两组血清CYFRA21-1水平均高于健康对照组。结论老年SAP患者血清CYFRA21-1的水平升高程度与病死率密切相关,和反复发作也有一定的关系,说明血清CYFRA21-1在老年SAP发生及发展过程中有一定作用。Objective To investigate the changes of non - small - cell lung cancer related antigen CYFRA21 -1 serum level in elderly patients with severe pneumonia and to evaluate the effects of such changes on the clinical prognosis. Methods Twenty - eight cases of elderly patients with severe pneumonia were divided into survival group （13 cases） and death group （15 cases）. Twenty -six healthy elderly people were used as control group. Once diagnosed as severe pneumonia, the patients were admitted into hospital immediately. CYFRA21 - 1 level were measured at the day of hospital admission, Five days after treatment, dischargement day or death respectively. Besides, blood pressure, SaO2, albumin, leukocyte counting, PaO2, PaCO2 and APACHE II of the patients were also measured. Results In 28 cases, there was no significant difference in clinical background between survival group and death group （P 〉 0. 05）. The CYFRA21 -1 level measured at the fifth day after treatment in death group was higher than that in survival group （P 〈 0. 05）, and the two groups were higher than that of healthy group. Conclusions The increase of CYFRA21 - 1 serum level is closely related to mortality rate and has certain relations with repeated attack. CYFRA21 -2 maybe play important roles in the onset and the development in elderly patients with severe pneumonia.

关 键 词：肺炎 非小细胞肺癌 相关抗原 

分 类 号：R734.204[医药卫生—肿瘤] R734.2[医药卫生—临床医学]