121例多发性骨髓瘤医院感染的临床分析  

Clinical Analysis of Nosocomial Infections for 121 Patients with Multiple Myeloma

作　　者：周玉萍[1] 邢红运[1] 

机构地区：[1]泸州医学院附属医院血液科,四川泸州646000

出　　处：《医学临床研究》2006年第8期1204-1205,共2页Journal of Clinical Research

摘　　要：【目的】探讨多发性骨髓瘤(MM)患者医院感染的临床特点。【方法】回顾性分析本院2000年1月至2005年6月住院治疗的121例多发性骨髓瘤患者的临床资料。【结果】121例MM患者发生医院感染33例,感染率(27.27%),粒细胞缺乏组医院感染率、感染致死率和平均感染日明显高于非粒细胞缺乏组(P<0.01、P<0.05)。感染部位以呼吸道为主,致病病原体以革兰阴性杆菌、革兰阳性球菌和真菌为主。MP和COMP方案化疗患者的感染率(20%和23.08%)与VAD组的(64.71%)相比有显著性差异(P<0.01)。【结论】多发性骨髓瘤医院感染发病率高,应积极治疗和预防。[Objective]To clarify the features of nosocomial infections for patients with multiple myeloma （MM）. [Methods]One hundred and twenty-one cases of MM treated in our hospital from Jan. 2000 to Jun. 2005 were analyzed retrospectively. [Results] Among 121 patients with MM, 33 patients （27.27 % ） suffered from nosocomial infections. The incidence of infections and the case mortality in the granulocytopenia group were significantly higher than those in the non-granulocytopenia group（ P〈0. 01）. Most of the infections took place in the respiratory tract , and the major infective microorganisms were gram-negative bacilli, gram-positive cocci and fungi. The incidence rates of infections in patients treated with the MP and COMP protocols were 20% and 23.08% respectively, which were significantly different from those in patients treated with the VAD protocols（64.71%）. [Conclusion]The incidence of nosocomial infections in patients with multiple myeloma is high. These patients should be given more active treatments and prophylaxes.

关 键 词：多发性骨髓病 交叉感染 

分 类 号：R733.3[医药卫生—肿瘤]