显微外科手术结合放疗治疗小脑髓母细胞瘤的临床疗效分析  

Analysis of Clinical Efficiency of Medulloblastoma Treated by Microsurgery Assisted with Irradiation

作　　者：毛更生[1] 只达石[2] 张文学[3] 

机构地区：[1]武警总医院神经外科,北京100039 [2]天津医科大学总医院神经外科,天津300052 [3]天津市环湖医院放疗科,300060

出　　处：《医学临床研究》2006年第8期1234-1236,共3页Journal of Clinical Research

摘　　要：【目的】探讨显微外科手术结合全脑全脊髓放疗治疗小脑髓母细胞瘤的临床效果及预后。【方法】回顾性分析29例髓母细胞瘤病人资料，患者均行头部CT和（或）MRI检查，全部病例行显微手术切除肿瘤，切除标本经病理证实，术后辅以全脑全脊髓放疗。【结果】29例中，肿瘤全切除18例，次全切除11例。术后症状均得到明显改善，随访4～116个月。三年、五年生存率分别为79．31％和75．86％。【结论】对小脑髓母细胞瘤应尽量做到手术全切除，以解除脑脊液循环梗阻，术后辅以全脑全脊髓放射治疗等综合治疗。可明显减少或延缓复发，改善生活质量，延长生存期。[Objective]To investigate the prognosis of medulloblastoma treated by microsurgery assisted with craniospinal axis irradiation. [Methods]The clinical data including clinical features, image, microsurgical procedures, prognosis and radiation of 29 cases of medulloblastoma were analyzed retrospectively. All cases of medulloblastoma were confirmed by routine clinical pathology and assisted with craniospinal axis irradiation. [Results]All cases of medulloblastoma were microsurgically removed in which 18 were totally removed and 11 cases were subtotally removed. All cases were improved after follow-up of 4～116 months. The three years and five years survival rates of patients were 66.2% and 62.1% respectively after assisted craniospinal axis irradiation and /or chemotherapy. [Conclusion]With total removal of medulloblastoma to relieve circulatory obstruction of cerebrospinal fluid, supplemented with craniospinal axis irradiation and/or chemotherapy, the recrudescence of tumor could be reduced and life quality improved.

关 键 词：成神经管细胞瘤/外科学 小脑 成神经管细胞瘤/放射疗法 显微外科手术 

分 类 号：R739.4[医药卫生—肿瘤]