胃粘膜灶性异型增生的形态研究  

Morphologic Study of Focal Dysplasia in Gastritis

作　　者：王仰坤[1] 马乃绪[1] 王恩升[1] 钟汉馨 王云玲 

机构地区：[1]解放军第91医院,河南省洛阳市解放军150医院

出　　处：《中国肿瘤临床》1996年第9期657-658,共2页Chinese Journal of Clinical Oncology

摘　　要：３９６例活检胃粘膜炎症性病变中１９．９％找见异型增生灶，其由单个至１０多个细胞构成，可向管腔内或外突起。其检出率为糜烂性胃炎的８．０％，浅表性胃炎的１０．９％，萎缩性胃炎的３８．４％，慢性溃疡的１８．９％。灶性异型增生细胞ＰＣＮＡ阳性表达６１．３％；ＡｇＮＯＲ计数３．８１～８．７２个，提示ＰＣＮＡ和ＡｇＮＯＲ检测可帮助判断胃粘膜灶性异型增生。cases of biopsied gastric mucosa with inflammation were studied pathologically. Focal dysplasia was found in 19.9% of the cases. Most of the foci consisted of 1-10 cells. The detectable rate of focal dysplasia was 8.0% in erosive gastritis,10. 9% in superficial gastritis,38.4% in atrophic gastritis and 18. 9% in chronic gastric ulcer.The positive rate of PCNA(proliferating cell nuclear antigen)in the focal dysplastic cells reached 61.3%.The count of AgNOR(nucleolar organizer regions) was between 3.81-8. 72.It indicates that the detection of PCNA and AgNOR might be helpful in the diagnosis of focal dysplasia of gastric mucosa.

关 键 词：胃粘膜异型增生 增殖细胞核抗原 AGNOR染色 

分 类 号：R573.04[医药卫生—消化系统] R735.204[医药卫生—内科学]