羟基喜树碱联合顺铂治疗晚期食管鳞癌临床观察  

Objective of Curative Effect of Combination Chemotherapy with HCPT and Cisplatin for Advanced Esophageal Cancer

作　　者：张国华[1] 刘士霞[2] 

机构地区：[1]广东省人民医院,510120 [2]河南第一荣康医院,453003

出　　处：《实用癌症杂志》2006年第3期291-292,共2页The Practical Journal of Cancer

摘　　要：目的观察羟基喜树碱（HCPT）联合顺铂（PDD）组成的HP方案对晚期食管鳞癌的近期疗效和不良反应。方法43例晚期食管癌患者采用HP方案：羟基喜树碱（HCPT）6mg／m^2，d1-5，静脉点滴；顺铂（PDD）20mg／m^2，d1-5，静脉点滴。21天为1个周期。化疗2个周期后评价近期疗效和不良反应。结果43例均可评价，CR5例（11．6％）、PR17例（39．5％）、SD15例（34．9％）和PD6例（14．0％）。近期总有效率51．2％。主要不良反应为骨髓抑制和胃肠道反应，多为Ⅰ～Ⅱ度，患者均可耐受，不影响治疗正常进行。结论HP方案治疗晚期食管癌近期疗效好，不良反应少，值得临床推广应用。Objective To evaluate the efficacy and safety of the combination of 10-hydroxycamptothecin（HCPT） and cisplatin（PDD） in the treatment of advanced esophageal cancer. Methods The chemotherapy was used HCPT 6 mg/m^2 daily for five days and PDD 20mg/m^2 daily for five days,one cycle was 21 days for 43 patients with advanced esophageal cancer. Results Object response rates were obtained in all patients. The overall response rate was 51.2 % with 5 complete response （CR） and 17 partial response （PR）. The adverse reaction mainifested mainly the yeaction of gastroiontestinal tract and the suppression of bone marrow. there as no treatment-related death.Conclusion HCPT plus PDD is active and tolerable in treatment of advanced esophageal cancer, it is valuable to be used extensive in clinic.

关 键 词：食管肿瘤 化学治疗 疗效观察 

分 类 号：R735.1[医药卫生—肿瘤]