11H-二苯并[b，f]硫杂-10-酮的合成  

Synthesis of 11H-Dibenzo[b,f] thiepin-10-one

作　　者：陈文华[1] 袁根林 

机构地区：[1]常州工程职业技术学院应用化学系,江苏常州213004 [2]常州康瑞化工有限工司,江苏常州213034

出　　处：《中国医药工业杂志》2006年第8期518-519,共2页Chinese Journal of Pharmaceuticals

摘　　要：邻氯苯甲醛与苯硫酚经Ullmann缩合、还原、浓盐酸氯化、氰化、水解及闭环等反应制得抗炎镇痛药扎托洛芬的中间体11H-二苯并[b,f]硫杂(艹卓)-10-酮,总收率48%。11H-Dibenzo [b, f] thiepin-10-one, a key intermediate of anti-inflammatory zaltoprofen, was synthesized from 2-chlorobenzaldehyde by Ullmann condensation, reduction with NaBH4, chloration with conc. HCl, cyanidation, hydrolysis and cyclization with an overall yield of 48 %.

关 键 词：11H-二苯并[b f]硫杂[艹卓]-10-酮 扎托洛芬 非甾体消炎药 中间体 合成 

分 类 号：R979.1[医药卫生—药品]