利巴韦林鼻用温敏凝胶热力学和流变学性质研究  

Thermodynamic and Rheological Properties of Thermosensitive Gels for Nasal Delivery of Ribavirin

作　　者：宋涛[1] 王东凯[2] 高红[2] 张翠霞[2] 纪标[2] 

机构地区：[1]泰山医学院药学院,山东泰安271016 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2006年第8期540-542,共3页Chinese Journal of Pharmaceuticals

摘　　要：考察了不同浓度泊洛沙姆407、PEG 6000和泊洛沙姆188及处方最利巴韦林对鼻用温敏凝胶的热力学[胶凝温度(T_1)、胶融温度(T_2)]和流变学性质(黏度)的影响。结果表明,凝胶的T_1和黏度均与泊洛沙姆407浓度呈负相关,而T_2则与其呈正相关；利巴韦林和相应辅料对凝胶的T_1、T_2和黏度都有不同程度的影响。Effects of different concentrations of Poloxamer 407, PEG 6000 and Poloxamer 188 and formulated amount of ribavirin on thermodynamic [gelation （T1） and gel melting （T2） ] and rheological （viscosity） properties of nasal thermosensitive gels were investigated. The results showed there was a negative correlation between T1, viscosity and Poloxamer 407concentration. A positive correlation was founded between T2 and Poloxamer 407 concentration. The other two excipients and ribavirin had different degrees of effects on T1, T2 and viscosity.

关 键 词：利巴韦林 鼻用温敏凝胶 热力学性质 流变学性质 泊洛沙姆407 

分 类 号：R944.9[医药卫生—药剂学]