乳腺良性病变及乳腺癌雌、孕激素受体的研究  

Study on the expression of estrogen and progesterone receptors in breast benign lesion and cancer

作　　者：陈东[1] 高延昭[1] 赵庆夏[1] 魏丽[1] 李新荣[1] 李文才[1] 王江[1] 

机构地区：[1]河南医科大学病理学教研室

出　　处：《河南医科大学学报》1996年第4期37-40,共4页Journal of Henan Medical University

摘　　要：应用酶联亲和组化法及网格点计数方法，对３０例乳腺癌、３８例纤维腺瘤、３９例小叶增生及２３例非癌组织的雌激素受体（ＥＲ）和孕酮受体（ＰＲ）及细胞密度进行检测和分析。结果：①纤维腺瘤、小叶增生及非癌组织中ＥＲ、ＰＲ的阳性率均分别低于癌中的表达（Ｐ＜０．０５），纤维腺瘤与小叶增生之间受体表达无显著性差异（Ｐ＞０．０５）。②各组病变中细胞密度的高低与受体阳性表达有关（Ｐ＜０．０５）。提示：乳腺良性病变中ＥＲ、ＰＲ阳性率的不同，为临床内分泌治疗提供理论依据。The determination and analysis of estrogen receptor(ER) and progesterone receptor(PR)and cellularity were performed On 30 cases of breast cancer,38 cases of fibroadenoma,39 cases of lobular hyperplasia and 23 non-malignant tissues with the enzyme-linked affinity histochemistry assay and point-counting method. The results showed that the positive rates of ER and PR in fibroadenomas,lobular hyperplasia and non-malignant tissues were significantly lower than those in breast cancer(P<0. 05). There was no significant difference between the receptor positive rates of the fibroadenoma and those of lobular hyperplasia. There was a positive correlation between the receptor value and cellularity in different breast benign and malignant lesions(P<0.05).This study suggests that the presence of ER and PR in breast lesions might provide theoretical basis for the clinical endocrine therapy.

关 键 词：乳腺癌 纤维腺瘤 雌激素受体 孕激素受体 

分 类 号：R737.9[医药卫生—肿瘤]