小脑延髓池注射谷氨酸单钠对猫创伤性脑水肿的影响  

Effects of sodium glutamate on traumatic brain edema in cats

作　　者：于明琨[1] 朱诚[1] 张光霁[1] 

机构地区：[1]第二军医大学长征医院神经外科

出　　处：《第二军医大学学报》1996年第3期233-235,共3页Academic Journal of Second Military Medical University

摘　　要：目的：探讨兴奋性氨基酸对创伤性脑水肿的影响及作用机理。才法：在已建立的猫创伤性脑水肿模型基础上，伤后２０ｍｉｎ小脑延髓地内注入谷氨酸单钠溶液，伤后６ｈ测定两侧大脑半球脑含水量及阳离子含量变化。结果：与对照组比较，脑含水量及Ｎａ＋，Ｃａ２＋含量明显增加；Ｋ＋，Ｍｇ２＋含量则相应降低，这种变化具有剂量依赖性。结论：谷氨酸有加重创伤性脑水肿的作用，谷氨酸使Ｎａ＋和Ｃａ２＋内流增加可能是其加重脑水肿的主要病理生理机理。To evaluate the effect and mechanism of excitatory amino acids on traumatic brain edema.Methods: Using a established model of traumatic brain edema in cats, we injected the solutions of sodium glutamate into cerebellomedullary cistern of cats 20 min post-traumatic brain injury and measured the contents of brain tissue water, cation in the bilateral cerebral hemispheres 6 h posti-njury. Results: There were significant increases in the contents of brain tissue water , Na￣+ and Ca2￣+, whereas there were marked decreases in the contents of brain K￣+ and Mg￣2+ as compared with the control group. The changes above were dose-dependent.Conclusion : Glutamate may contribute to traumatic brain edema. The increases of Na￣+ and Ca￣2+ influx may be the main pathophysiological mechanism of glutamate in exacerbating brain edema post-injury.

关 键 词：颅脑损伤 脑水肿 谷氨酸单钠 

分 类 号：R651.15[医药卫生—外科学]