抗精神病药对男性精神分裂症患者垂体-性腺轴的影响  

Effects of antipsychotic on pituitary-gonadal axis in male patients with schizophrenia

作　　者：曹栋[1] 谢世平[1] 陈启豹[1] 袁勇贵[1] 方群[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029

出　　处：《临床精神医学杂志》2006年第4期209-211,共3页Journal of Clinical Psychiatry

摘　　要：目的:研究氯丙嗪、利培酮、奎硫平及奥氮平对男性精神分裂症患者垂体性腺轴的影响。方法:88例首发男性精神分裂症患者随机分为氯丙嗪组、利培酮组、奎硫平组及奥氮平组,检测治疗前、治疗4周及8周血清促卵泡素(FSH)、黄体生成素(LH)、催乳素(PRL)、睾酮(T)的水平变化。结果:氯丙嗪组治疗8周后,血清PRL水平显著高于治疗前。利培酮组在治疗4周及8周后PRL水平均显著高于治疗前,治疗8周后T及LH水平显著低于治疗前。奎硫平组在治疗4周及8周后血清PRL、LH、T水平与治疗前比较差异均无显著性。奥氮平组治疗4周后PRL水平显著高于治疗前,治疗8周后即与治疗前差异无显著性。结论:奎硫平对垂体性腺轴激素水平无明显影响。Objective：To investigate the effects of chlorpromazine, risperidone, quetiapine and olanzapine on pituitary-gonadal （PG） axis in male patients with schizophrenia. Method： 88 first onset male inpatients with schizophrenia were randomly divided into four subgroups receiving chlorpromazine, risperidone, quetiapine and olanzapine respectively. Before the treatment and after the treatment of 4 weeks and 8 weeks, serum follicle stimulating hormone（FSH） ,luteinizing hormone（LH） ,prolactin（PRL）,testosterone（T） levels were detected. Results：Serum level of PRL of chhrpromazine group at week 8 were significantly higher than those of the basehne. Serum PRL levels of risperidane group at week 4 or at week 8 were significantly higher than those of the baseline.Serum levels ofT and LH of risperidone group were significantly lower than those of the baseline. Serum PRL level of olanzapine group at week 4 was significantly higher than those of the baseline.Serum levels of PRL,LH and T of quetiapine group at baseine, week 4 and week 8 were similar. Condusion：Quetiapine has little influence on PG axis.

关 键 词：抗精神病药 精神分裂症 垂体-性腺轴 

分 类 号：R749.053[医药卫生—神经病学与精神病学]