射频联合抑酸剂加抗反流药治疗Barrett食管的临床观察  

Clinical effect of radio-frequency(RF)combining acid suppression and anti-reflux in endoscopic treatment of Barrett′s esophagus(BE)

作　　者：赵玲[1] 温俊良[1] 王文件 魏萍[1] 刘运贤[2] 翟玉荣[1] 董小妹[1] 施媛[1] 

机构地区：[1]淮北矿工总医院消化科,安徽淮北235000 [2]淮北矿工总医院病理科,安徽淮北235000

出　　处：《皖南医学院学报》2006年第3期204-206,共3页Journal of Wannan Medical College

摘　　要：目的:观察射频联合抑酸剂加抗反流药治疗Barrett食管的临床疗效。方法:对35例经内镜和病理确诊的Bar-rett食管病人,分别采用射频联合质子泵抑制剂、多潘立酮(治疗组)和质子泵抑制剂、多潘立酮(对照组)治疗,于用药和射频末次治疗后第3、6个月进行内镜和病理复查。结果:治疗组20例总有效率分别为35%、77.78%,而对照组则分别为0、15.38%(P<0.01)。治疗组除出现短暂胸骨后疼痛、吞咽疼痛、低热外,无出血、穿孔等并发症。结论:射频联合抑酸剂加抗反流药治疗Barrett食管疗效确切。Objective： To explore the clinical effect of RF with acid suppression and anti-reflux in endoscopic treatment of BE. Methods ： Out of 35 patients with BE,20 patients were treated with RF combining proton pump inhibitor（PPI） and domperidone, and the rest were treated with PPI and domperidone. The results were observed by endoscopy and pathology after 3 or 6 months of treatment. Results： With RF combining PPI and domperidone, the total effective rate of BE was 35% and 77.78% respectively 3 or 6 months later. While the total effective rate accounted for only 15. 38% after 6 months with PPI and domperidone （P 〈 0.01 ）. Complications as transient odynophagia, chest pain and low fever in patients with RF combining PPI and domperidone occurred, but no bleeding and perforation happened. Conclusion ： The clinical experience shows that RF combining PPI and anti-reflux is effective in treating BE.

关 键 词：BARRETT食管 射频 抑酸 

分 类 号：R573.9[医药卫生—消化系统]