许旺细胞标记物GFAP与肌上皮细胞标记物α-SMA在涎腺腺样囊性癌中共表达  

Coexpression of Schwann cell marker GFAP and myoepithelial cell markerα-SMA in salivary adenoid cystic carcinoma

作　　者：孙沫逸[1] 陈伟[1] 杨连甲[2] 董绍忠[2] 

机构地区：[1]第四军医大学口腔医学院口腔颌面外科,西安710032 [2]第四军医大学口腔医学院,口腔病理科,西安710032

出　　处：《中华口腔医学杂志》2006年第8期461-463,共3页Chinese Journal of Stomatology

基　　金：国家自然科学基金(30271424);陕西省自然科学基金(2002C2-06)

摘　　要：目的检测许旺细胞标记物胶原原纤维酸性蛋白(GFAP)与肌上皮细胞标记物α-平滑肌肌动蛋白(α-SMA)在涎腺腺样囊性癌(ACC)中的表达情况,并探讨GFAP、α-SMA与ACC嗜神经侵袭的关系。方法用免疫组织化学、免疫荧光双标记及激光共聚焦显微镜技术检测GFAP蛋白与α-SMA蛋白在ACC组织中的表达。结果在ACC组织中,GFAP蛋白与α-SMA蛋白均有表达,二者在同一肿瘤性肌上皮样细胞胞质中共表达。结论ACC中肿瘤性肌上皮样细胞发生许旺细胞分化并侵袭神经可能是ACC嗜神经侵袭的组织病理学基础。Objective To observe the expression of Schwann cell marker GFAP and myoepithelial cell marker α-SMA in salivary adenoid cystic carcinoma（ACC）, and to evaluate the relationship of GFAP. α-SMA and perineural invasion in ACC. Methods Immunohistochemical SABC method, double-label immunofluorescence and CLSM were used to detect the expression of GFAP and α-SMA proteins in salivary ACC tissue samples. Results In salivary ACC tissue samples, both GFAP and α-SMA proteins were positive, which were coexpressed in cytoplasm of the same onco-myoepithelial cells. Conclusions There may be Schwann cell differentiation in onco-myoepithelial cell of salivary ACC, and it may be the pathological base of perineural invasion in salivary ACC.

关 键 词：癌 腺样囊性 许旺氏细胞 肌上皮细胞 

分 类 号：R739.8[医药卫生—肿瘤]