瘦素、抵抗素、2型糖尿病间的相关性研究  

Correlation among plasma leptin,resistin an type 2 diabetes mellitus

作　　者：毛红仙[1] 汪大望[2] 胡素银[1] 郑景晨[2] 吴俊琪[1] 徐瑞龙[1] 

机构地区：[1]浙江省金华市中心医院,浙江金华321000 [2]温州医学院附属第一医院,浙江温州325000

出　　处：《中国病理生理杂志》2006年第8期1647-1649,共3页Chinese Journal of Pathophysiology

基　　金：金华市科技局课题基金资助项目(No.2004-1-345)

摘　　要：目的:研究血浆瘦素与抵抗素、体重指数、腰围、腰臀比、血脂、胰岛素敏感性指数等的关系。方法:对43例新诊断2型糖尿病患者及37例糖耐量正常者,测定空腹血浆瘦素、胰岛素、血糖、血脂及抵抗素浓度。结果:相关分析显示性别、体重指数(BM I)、腰围、腰臀比、胰岛素与瘦素呈显著正相关(r分别为0.623,0.534,0.516,0.302,0.354,均P<0.01),IAI与瘦素呈显著负相关(r=-0.373,P<0.01),甘油三酯、胆固醇空腹血糖与瘦素无明显相关。瘦素与抵抗素无相关性(r=0.101,P>0.05)。结论:空腹血浆瘦素水平与肥胖程度、胰岛素抵抗呈显著正相关,与抵抗素无关。瘦素可能与2型糖尿病的发病有关。AIM： To assess the association of resistin, obesity, serum lipid levels and insulin resistance with plasma leptin. METHODS： The concentrations of fasting serum glucose, insulin, lipid profiles, plasma resistin and leptin were assayed in 80 cases （ including 37 controls with normal glucose tolerance and 43 patients with type 2 diabetes mellitus）. RESULTS： Fasting plasma leptin level was positively correlated with sex, body mass index （BMI）, waist circumference （WC）, waist -hip ratio and fasting serum insulin （F Ins） （P 〈 0. 01 ）. Fasting plasma leptin level was negatively correlated with insulin sensitivity index （r = -0. 373, P 〈 0. 01 ）. There was no correlation between the concentrations of plasma leptin and FPG, TG, TC and resistin （ P 〉 0. 05 ）. CONCLUSION： Fasting plasma leptin level is positively correlated with obesity and insulin resistance, not resistin. Leptin may play a role in the pathogenesis of type 2 diabetes mellitus.

关 键 词：瘦素 抵抗素 肥胖症 糖尿病 

分 类 号：R363[医药卫生—病理学]