内皮脂酶与动脉粥样硬化  

Endothelial lipase and atherosclerosis

作　　者：许灿新[1] 王春[1] 秦旭平[1] 廖端芳[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国病理生理杂志》2006年第8期1657-1659,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30171048)

摘　　要：Endothelial lipase(EL),a newly described member of the triglyceride lipase gene family,displays a previously phospholipase A1 activity,remodels high density lipoprotein(HDL) particle and reduced plasma HDL-cholesterol levels and the ability to joint to scavenger receptor class B type 1(SR-B1).Furthermore,EL also increases cellular apolipoprotein B-containing lipoprotein uptake,monocyte adhesion and infiltration into the tissues.Recently,some studies showed that the vascular atherosclerotic lesions were markedly attenuated in EL deficient mice compared with control,suggesting that EL may play a significant role in the formation of atherosclerotic lesions.Endothelial lipase （ EL）, a newly described member of the triglyceride lipase gene family, displays a previously phospholipase AI activity, remodels high density lipoprotein （HDL） particle and reduced plasma HDL - cholesterol levels and the ability to joint to scavenger receptor class B type 1 （ SR - BI ）. Furthermore, EL also increases cellular apolipoprotein B -containing lipoprotein uptake, monocyte adhesion and infiltration into the tissues. Recently, some studies showed that the vascular atberosclerotic lesions were markedly attenuated in EL deficient mice compared with control, suggesting that EL may play a significant role in the formation of atherosclerotic lesions.

关 键 词：内皮脂酶 动脉硬化 脂蛋白类 HDL胆固醇 

分 类 号：R363[医药卫生—病理学]