腹腔动脉输注化疗联合热疗治疗供血动脉闭塞的肝癌  

Treatment of Hepatocellular Carcinoma with Occlusion of Supplying Artery by Combined Application of Intraarterial Infusion Chemo-therapy and Hyperthermia

作　　者：程先鸣 倪荣清 潘伟 王红民[1] 余意[1] 

机构地区：[1]汉口铁路医院肿瘤科,武汉430012

出　　处：《放射学实践》2006年第8期824-826,共3页Radiologic Practice

摘　　要：目的:探讨腹腔动脉输注化疗联合热疗治疗供血动脉闭塞的肝癌的疗效和不良反应。方法:47例接受过TACE的原发性肝癌病例,腹腔动脉注入DDP60mg,5FU1000mg,MMC10mg,拔除导管压迫止血后立即在内生场热疗机上对肝区进行热疗,时间为60～90分钟/次,2次/周,每次输注化疗后热疗6～8次,热疗时直肠内温度在40.2℃～42.8℃。结果:47例患者治疗后36例肝脏肿瘤缩小,占76.6%;33例AFP阳性的患者26例转阴或明显下降。不良反应较轻。结论:腹腔动脉输注化疗联合热疗治疗供血动脉主干闭塞的肝癌疗效肯定,毒性较低,值得总结和探索。Objective： To search curative and adverse effects of intraarterial infusion chemo-therapy combined with hyperthermia in treatment of hepatocellular carcinoma （HCC） with occluded supplying artery. Methods：47 cases of HCC with occluded supplying artery due to previous trancatheter arterial chemoembolization （TACE） were studied. DDP 60mg,5-FU 1000mg and MMC 10mg were infused into coeliac artery,then hyperthermia was performed on the local liver region by endogeny magnetic field machine after the procedure immedcately. The course of hyperthermia was 60～0min/each procedure, 2 procedures perweek and 6～8 times hyperthermia after per chemo-therapy. Intrarectal temperature was 40.2℃～ 42. 8℃ during the hyperthermia. Results： In 47 cases, hepatic mass reduced in size in 36 cases, with the efficiency rate of 76. 6% ;In 26 of 33 cases with elevated AFP,it converted to negative or decreased obviously,and adverse reactions were mild. Conclusion：The combined application of intraarterial infusion chemotherapy and hyperthermia is valuable for the treatment of HCC with occlusion of supplying artery,with high curative effect and mild noxious effects.

关 键 词：腹腔动脉输注化疗 高温 热疗 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤] R818.051[医药卫生—临床医学]