2型糖尿病患者高尿酸血症与代谢综合征的相关性  

Relationship between Serum Uric Acid Level and the Metabolic Syndrome in Type 2 Diabetes

作　　者：张宝生[1] 赵伟[1] 李美[1] 张宏[1] 

机构地区：[1]天津医科大学代谢病医院,天津300070

出　　处：《中国慢性病预防与控制》2006年第4期264-266,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的研究2型糖尿病患者中血清尿酸水平在代谢综合征发病中的作用,探讨其可能的发病机制。方法627例2型糖尿病患者按血清尿酸水平分两组:高尿酸水平组77例,非高尿酸组(尿酸水平偏低或正常组)550例,观察血清尿酸水平与代谢综合征主要参数的相关性。结果血尿酸与血压、甘油三酯、体质指数呈正相关(P<0.01),与高密度脂蛋白胆固醇呈负相关(P<0.01);代谢综合征患病率高尿酸组为74.03%,非高尿酸组为48.00%(P<0.01)。结论2型糖尿病患者血尿酸水平与多因素相关,提示2型糖尿病高尿酸血症可能是代谢综合征等发病的危险因素之一。Objective To study the effect of serum uric levels on the metabolic syndrome and its pathogenesis. Methods 627 cases were divided into 2 groups according to their uric acid levels, and then the relationship between serum uric acid and the chief parameters of the metabelic syndrome were observed. Results There was a positive correlation between uric acid levels and blood pressure, triglycerides, body mass index（P〈0.01）, and a negative correlation between uric acid levels and HDL-cholesterol（P〈0.01）. The prevalence of metabelic syndrome was higher in patients with hyperuricaemia than those without it （P〈0.01）. Conclusion There were many factors rehtted to serum uric acid levels in type 2 diabetic patients, it suggested that hyperuricemia might be one of the risk factors for metabolic syndrome.

关 键 词：糖尿病 2型 尿酸 代谢综合征 

分 类 号：R158.7[医药卫生—营养与食品卫生学]