叶酸、蛋氨酸摄入量,MTR、TS基因多态与结直肠癌关系的巢式病例对照研究  

FOLATE,METHIONINE,AND POLYMORPHISMS OF METHIONINE SYNTHASE,THYMIDYLATE SYNTHASE AND SUSCEPTIBILITY OF COLORECTAL CANCER

作　　者：陈坤[1] 宋亮[1] 俞维萍[1] 蒋沁婷[1] 张扬[1] 范春红[1] 

机构地区：[1]浙江大学医学院流行病教研室,杭州310031

出　　处：《营养学报》2006年第4期342-345,349,共5页Acta Nutrimenta Sinica

基　　金：国家自然科学基金(No.30471492)

摘　　要：目的:研究蛋氨酸合酶(methioninesynthase,MTR)、胸苷酸合酶(thymidylatesynthase,TS)基因多态性,叶酸、蛋氨酸摄入量与结直肠癌易感性的关系。方法:采用巢式病例对照研究设计(病例140例和对照343例),通过非条件Logistic回归模型分析各多态与结直肠癌易感性的关系,及其与叶酸、蛋氨酸摄入量之间的联合作用。结果:MTR2756G等位基因携带者患结直肠癌的风险显著增高(OR=2.04,95%CI,1.22～3.39)。TS5’-UTR多态与叶酸摄入量之间的联合作用与结直肠易感性的关系有统计学意义(P=0.01)。结论:MTR2756G等位基因是结直肠癌的危险因素,TS5’-UTR多态与叶酸摄入量之间可能存在交互作用。Objective： To investigate the associations of folate, methionine, methionine synthase （MTR） and thymidylate synthase （TS） polymorphisms with colorectal cancer （CRC） susceptibility. Method： A nested case-control study was designed, which included 140 CRC patients and 343 control subjects. Independent effects of each polymorphism and their combinative effects with folate, methionine intake were estimated by unconditional Logistic regression model. Results： Compared to wild types, MTR2756G allele carders had a significant elevated risk of colorectal cancer （OR=2.04, 95%CI, 1.22-3.39）. The combined effects of folate intake and TS 5＇-UTR polymorphism were significantly associated with CRC （P=0.01）. Conclusion： MTR2756G allele may be a risk factor of CRC, and interaction may exist between folate intake and TS 5＇-UTR polymorphism.

关 键 词：蛋氨酸合成酶 胸苷酸合成酶 结直肠癌 基因多态性 叶酸 蛋氨酸 

分 类 号：R735.3[医药卫生—肿瘤]