Gln与rhGh对肝硬化病人肠黏膜屏障的影响  

Effects of glutamine and recombinant human growth hormone on intestinal barrier in patiens with hepatic cirrhosis

作　　者：邓宇[1] 许瑞云[1] 刘波[1] 陈郁鲜[1] 

机构地区：[1]中山大学附属第三医院肝胆外科,广东广州510630

出　　处：《中国现代医学杂志》2006年第15期2336-2338,共3页China Journal of Modern Medicine

摘　　要：目的观察Gln与rhGh各单独应用及联合应用对肝硬化病人小肠黏膜屏障形态学和功能学的影响。方法20个肝硬化病人随机分成四组,给予等氮等热量营养支持7d,Gln+rhGh组口服Gln[0.3g/(Kg·d)]和皮下注射rhGh(10U/d);Gln组口服Gln;rhGh组应用皮下注射rhGh;CONT对照组应用相应安慰剂。观察治疗前后患者小肠黏膜通透性和十二指肠黏膜绒毛高度和隐窝深度的变化,分别比较。结果Gln+rhGh组治疗后小肠黏膜通透性有显著性的降低(P<0.05),且显著低于其他三组(P<0.05);十二指肠黏膜绒毛高度和隐窝深度有显著性的增高(P<0.05),且显著高于其他三组(P<0.05)。结论Gln与rhGh联合应用能减低肠道黏膜的通透性和维持其形态学的完整。[Objective] To investigate the morphologic and functional alterations in intestinal mucosa of the cirrhotic patients after 7 day＇s application of Gin combined with recombinant human growth hormone （rhGh）. [Method] 20 patients were randomly allocated to 4 groups. According to grouping, patients daily received oral Gin [（0.3 g/（Kg· d）] and rhGh （10U/d）, Gin only, rhGh only and placebos only. All patients were restricted to isocaloric and isonitrogenic intakes everyday. Changes in intestinal permeability, villus heights and crypt depths of mucosa in the second part of duodenum were investigated after 7 day＇s trial, and comparisions were made among groups as well as between before and after the trial in the same group. [Results] In Gin＋rhGh group, pest-trial intestinal permeability decreased significantly than that of pre-trial （P 〈0.05）, and than those in the other 3 groups （P 〈0.05）; villus heights and crypt depths increased significantly than that of pre-trial （P 〈0.05）, and than those in the other 3 groups （P 〈0.05）. [Condusion] Application of Gin combined with rhGh on cirrhotic patients can prevent deterioration of gut permeability, preserve mucosal structure.

关 键 词：谷氨酰胺 生长激素 肝硬变 小肠黏膜/病理学 

分 类 号：R575.2[医药卫生—消化系统]