原发性皮肤间变性大细胞淋巴瘤4例  

Primary cutaneous anaplastic large cell lymphoma: a report of four cases

作　　者：王振[1] 董耀煊 

机构地区：[1]山东省烟台市莱阳中心医院病理科,265200 [2]山东省烟台市皮肤病防治所

出　　处：《中国麻风皮肤病杂志》2006年第8期646-648,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的：探讨原发性皮肤间变性大细胞淋巴瘤（ALCL）临床及病理特征。方法：复习4例患者的临床资料、肿瘤组织的病理形态和免疫表型。结果：4例中男3例，女1例，平均年龄为55．5岁。患者临床上均表现为皮下结节。光镜下以75％以上CD30^＋间变性大细胞弥漫浸润真皮及皮下脂肪组织为特征，多数瘤细胞表达T细胞免疫表型。随访3例12—36个月肿瘤均无复发或转移。结论：原发性皮肤ALCL是少见的低度恶性T细胞性淋巴瘤，预后较好。依据其组织病理学特征及免疫组化CD30阳性标记，可与其他恶性肿瘤进行鉴别。Objective： To analyze the clinicopathologic characteristics of primary cutaneous anaplastic large cell lymphoma （ALCL）. Methods： The clinical history, histopathological changes and expression in 4 cases of primary cutaneous ALCL were investigated. Results： There were 3 males and 1 female with an average age of 55.5 years. All patients presented with subcutaneous masses. The lymphoma was characterized by a dermal and subcutaneous infiltration of atypical large cells. More than 75 % of the neoplastic cells were CD30^＋ and expressed T- cell immunophenotype. No recurrences or metastases were found in the follow- up of 3 cases for 12 - 36 months. Conclusion： Primary cutaneous ALCL is a rare low- grade malignancy with a generally favorable outcome. This tumor can be differentiated from other malignant tumors by means of histopathologic features and positive expression of CD30.

关 键 词：淋巴瘤 免疫组化 病理学 

分 类 号：R739.5[医药卫生—肿瘤] R733.1[医药卫生—临床医学]