γ-干扰素对感染都匀亚洲牛带绦虫小鼠血清γ-GT活性的影响  

Influence of γ-Interferon on the Activity of Serum γ-Glutanyl Transpeptide in the Mice Infected With Taenia Saginata Asiatica

作　　者：何小飞[1] 李溥[1] 欧燕芳[2] 党荣敏[1] 陈利红[1] 吴桂萍[1] 

机构地区：[1]黔南民族医学高等专科学校生化教研室,贵州都匀558003 [2]黔南民族医学高等专科学校第二附属医院检验科,贵州都匀558000

出　　处：《黔南民族医专学报》2006年第2期69-71,共3页Journal of Qiannan Medical College for Nationalities

基　　金：黔南医专科研基金资助项目(No.200503)

摘　　要：目的探讨γ-干扰素(γ-IFN)对感染都匀亚洲牛带绦虫小鼠血清γ-谷氨酰转肽酶(γ-GT)活性的影响。方法采用都匀亚洲牛带绦虫感染小鼠制作动物模型,于感染后第4周、第8周皮下注射γ-IFN每天一次,每只小鼠10u,连续4周,抽血检测γ-GT活性并进行分析。结果比较两对照组,都匀亚洲牛带绦虫囊尾蚴入侵小鼠体内导致血清γ-GT活性曲线明显升高,比较两注射组,4周龄组的血清γ-GT活性曲线明显升高,而8周龄组的曲线则比较平稳。结论γ-IFN在8周龄注射比4周龄注射效果好,各组曲线作函数回归处理,呈现指数函数规律。Objective：To investigate the change of the activity of γ -Glutanyl Transpeptide （γ -GT） in serum of the mice infected with Taenia Saginata asiatica and treated with γ -interferon（ γ -IFN）. Methods： The mice infected with Taenia Saginata asiatica were treated with γ - IFN（10u/day） through Subcutaneous injections at fourth and eighth week after infection, All the mice were observed for the condition of injection at 4 weeks and at 8 weeks, Serum content of γ - GT were detected by diazo reaction. Results： Comparing the two control groups, the activity of serum γ - GT was increased after being invaded by the Taenia Saginata asiatica. Comparing the injecting groups , the activicy curve line of serum γ - GT was increased apparently at the 4 weeks, but the activicy curve line of serum γ - GT was relatively smooth and steady. Conclusion： This test resuhs showed indirectly that efficiency of γ - IFN against than that the Taenia Saginata asiatica aged 4 weeks. All the Taenia Saginata asiatica aged 8 weeks was better the curve lines were dealed with by the function regression and show the exponent function rule.

关 键 词：Γ-干扰素 Γ-GT 亚洲牛带绦虫 小鼠 都匀 

分 类 号：R714.22[医药卫生—妇产科学]