抗病毒口服液对兔眼结膜炎模型抗炎作用的研究  

Anti-inflammatory effect of Antivirus Oral Liquid in experimental rabbit's conjunctivitis model

作　　者：文洁[1] 俞励平[1] 孙素兰[1] 朱建梅[1] 叶青山[1] 袁广明[2] 

机构地区：[1]中山大学药物开发中心,广东广州510080 [2]中山大学中山医学院,广东广州510080

出　　处：《中成药》2006年第8期1160-1163,共4页Chinese Traditional Patent Medicine

摘　　要：目的:观察抗病毒口服液(Antivirus O ral L iqu id,AOL)对家兔金葡菌性结膜炎及刺激性结膜炎的治疗作用。方法:建立兔眼损伤金葡菌性结膜炎及斑蝥酊刺激性结膜炎模型,观察各组动物的眼刺激症状、细菌转阴率及结膜的组织病理学改变,并和氯霉素滴眼剂或舒目滴眼剂的治疗效果相比较。结果:1.AOL对家兔细菌性结膜炎具有明显抗炎作用,连续给药4 d后细菌转阴率>90%,其结膜充血及水肿症状比模型组明显减轻。2.AOL对刺激性兔眼结膜炎具有明显抗炎作用,给药1 d后眼结膜充血、水肿症状明显减轻;给药4 d后,其炎症已基本消失。结论:AOL对家兔金葡菌性结膜炎及刺激性结膜炎具有良好的疗效。AIM： To study the anti-inflammatory effect of the Antivirus Oral Liquid （AOL） in experimental rabbit conjunctivitis model. METHODS： Rabbit＇s taphococcus aureus conjunctivitis models and cantharides tincture conjunctivitis models were made to observe different groups of animalslsymptom of eye stimulation, negative rate of bacteria and conjunctiva histopathology. And then AOL compared with the effect of amphemycin gutta or Shumu gutta. RESULTS： It showed that AOL possessed significant anti-inflammatory effect on bacterial conjunctivitis. The negative rate of bacteria was more than 90% after being given AOL for 4 days successively. Compared with the models group, the hyperemia and edemda were markedly relieved. The result showed that AOL possessed significant anti-inflammatory effect on irritable conjunctivitis. The hyperemia and edema were markedly relieved at the second day after being given AOL, and the inflammatory symptoms had almost disappeared after being given AOL for 4 days successively. CONCLUSION ： AOL has a good effect on the therapy of staphylococcus aureus conjunctivitis and cantharides tincture.

关 键 词：AOL 斑蝥酊 金黄色葡萄球菌性结膜炎 刺激性结膜炎 

分 类 号：R285.6[医药卫生—中药学]