多孔状生物微晶玻璃修复下颌骨缺损的实验研究  

An experimental study on porus bioactive glass for relonstruction of mandibular defects in rabbits

作　　者：谈万业[1] 孙明霞[2] 魏奉才[1] 彭化海[1] 董作青[1] 王克涛[1] 

机构地区：[1]山东大学齐鲁医院口腔颌面外科,博士生主治医师山东250012 [2]山东大学齐鲁医院整形烧伤科,医师山东250012

出　　处：《口腔颌面修复学杂志》2006年第3期193-196,共4页Chinese Journal of Prosthodontics

基　　金：山东省自然科学基金(编号:Y99C05)

摘　　要：目的:探讨多孔状生物微晶玻璃植入实验兔下颌骨缺损中引导骨形成的作用,为骨组织的修复与重建筛选一种良好的骨移植替代材料。方法:12只成年新西兰大白兔,随机分为4组,每兔两侧下颌骨均制作1.0cm×0.8cm大小的贯通性骨缺损,实验侧植入多孔状生物微晶玻璃材料,对照侧植入自体骨骼。术后第2、4、8、12周时,分别处死一组动物,对标本进行影像学、组织学及扫描电镜检查,观察颌骨缺损处的成骨情况。结果:多孔状生物微晶玻璃植入体内后,并不引起明显的排斥反应,缺损周围类骨组织逐渐长入材料周边孔隙,并逐渐矿化成骨,术后12周时,材料与周围组织形成牢固的骨性连接。结论:多孔状生物微晶玻璃具有较强的修复骨缺损的能力,是一种较好的骨移植替代材料。Objective： The purpose of this study was to investigate the role of the bioactive glass in repairing rabbits＇ mandibular defects, and to find a substitute for bone reconstruction. Methods： Twelve Newzerland rabbits were divided into four groups. The same bone defect （1.0cm× 0.8cm） was made respectively in the bilateral mandible of every rabbit. The experimental groups were filled with the bioactive glass while the control with the autologous bone tissue. 2, 4, 8, 12 weeks after the operation, every three rabbits were killed and all the specimens were respectively observed by radiology, histology and SEM （Scanning Electron Microscopy） examinations. Results： There was no obvious immunologic rejection. New osteoid and bone tissue formed step by step between the material and the surrounding bone tissue.Osseous connection could be seen around the porous border of materials at the 12th week postoperation. Conclusion： Bioactive glass can be used to repair bone defects and would be a aceptable substitute for bone reconstruction.

关 键 词：生物微晶玻璃 骨缺损 骨形成 

分 类 号：R782.4[医药卫生—口腔医学]