丝裂霉素C局部应用联合羊膜移植治疗复发性翼状胬肉疗效分析  

Application of mitomycin C in amniotic membrane transplantation to treat recurrent pterygium.

作　　者：石楚宁 周广莉[1] 

机构地区：[1]广东省普宁市华侨医院,515300

出　　处：《广州医药》2006年第5期37-39,共3页Guangzhou Medical Journal

摘　　要：目的 探讨丝裂霉素C局部术中湿敷后联合冷藏羊膜移植术在复发性翼状胬肉手术中的应用效果。方法 72例复发性翼状胬肉被随机分为二组，实验组：在显微镜下逆向切除复发性胬肉，36例应用0．2mg／ml的丝裂霉素C术中湿敷5分钟；对照组：36例术中均不用丝裂霉素C。随后二组行冷藏单纯羊膜移植术。结果 手术后随访12～24月，应用丝裂霉素C组有3例复发，复发率8．3％；而对照组36例未在手术中使用丝裂霉素C的翼状胬肉患者，有12例复发，复发率33．3％，经x^2检验，x^2=37．16，P〈0．001，二组间有显著差异。结论 羊膜移植联合手术中使用丝裂霉素C局部湿敷，可明显减少复发性翼状胬肉手术的复发率。Objective To evalute the results of application of mitomycin C in anmioctic membrane transplantation to treat recurrent pterygium. Methods 66 patients with recurrent pterygium were performed with 0. 2mg/ml mitomycin C solution on the sclera for 5 minutes. The control group underwent surgical excision only. Then two groups were given anmiotic membrane transplantation. Results After a mean postoperative follow up of 12 to 24 months, 3 cases recurrences （8.3%） were observed in the mitomycin C treated patients and 12 （33.3%） in the control patients. The difference between two groups is significant （X^2= 37. 16, P 〈 0. 001 ） . No severe side effects appeared during follow up. Conclusion Our results confirm the efficacy of intraoperative mitomycin C in improving the success rate after pterygium surgical excision.

关 键 词：翼状胬肉 羊膜移植 丝裂霉素C 

分 类 号：R777.33[医药卫生—眼科] R473.77[医药卫生—临床医学]