20(S)-原人参二醇对肝癌间质血管密度和肿瘤细胞增殖活性的影响  

Influences of protopanaxdiol to interstitial microvascular density and proliferation activity of liver cancer

作　　者：秦俊杰[1] 杨艳秋[1] 李颖新[1] 冷吉燕[1] 

机构地区：[1]吉林大学第一医院,吉林长春130021

出　　处：《临床肝胆病杂志》2006年第4期260-261,共2页Journal of Clinical Hepatology

基　　金：长春市科技局资助项目(2004072)

摘　　要：探讨20(S)-原人参二醇对肝癌间质微血管密度和肿瘤细胞增殖活性的影响。建立肝癌动物模型,将实验动物分为五组,每组10只,分对照组、环磷酰胺组、20(S)-原人参二醇25mg/kg、50mg/kg、100mg／kg给药组,给药二周后处死动物,称肿瘤重量及肿瘤体积,制成组织切片,以备免疫组化应用。与对照组相比,给药组肿瘤间质血管密度低,其细胞增殖活性亦低,肿瘤的重量及体积明显减少,组间有显著性差异(P<0．01)。提示20(S)-原人参二醇抑制了肝癌间质血管密度及肿瘤细胞增殖活性,从而抑制了肿瘤生长。To discuss influence of protopanaxdiol to interstitial microvascular density and proliferation activity of liver cancer. To construct liver cancer animal models and the experimental animals are divided into five groups, each group includes ten animals. That is control group, CTX group, protopanaxdiol 25mg/kg, 50mg/kg, 100mg/kg group. After two weeks, all the experimental animals will be killed, we will determine tumor volume and weight, then deal it into tissue spices for immmunohistochemistry. To compare with control group, in protopanaxdiol groups, tumor interstitial microvascular density is lower, and its proliferation activity also lower, its volume and weight is lower distinguishly. It suggests that protopanaxdiol inhibites tumor interstitial microvascular density and its proliferation activity, finally inhibites tumor growth.

关 键 词：20(S)-原人参二醇 肝癌 间质血管密度 增殖细胞核抗原 

分 类 号：R735.7[医药卫生—肿瘤]