高压氧治疗后立即放射治疗宫颈癌临床疗效观察  

Treating cervical cancer with radiotherapy combined with hyperbaric oxygen treatment

作　　者：喻道元[1] 周炜[2] 陈佳君[1] 庞军娥[1] 

机构地区：[1]华中科技大学同济医学院附属荆州医院高压氧科,荆州434020 [2]华中科技大学同济医学院附属荆州医院肿瘤科,荆州434020

出　　处：《中华物理医学与康复杂志》2006年第8期535-536,共2页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的探讨高压氧(HBO)治疗后立即放射治疗宫颈癌的疗效和应用价值。方法随机选择确诊为Ⅱ～Ⅲ期宫颈癌的患者58例,其中28例设为HBO组,30例为对照组。2组均常规采用60Co外照射+腔内后装治疗,HBO组在每次放射治疗前行HBO治疗,出舱后25 min内行放射治疗。结果HBO组完全缓解率(CR)为75．0％,总有效率(CR+PR)为92．8％,3年生存率为71．4％,局部复发率为10．7％,与对照组比较,差异有统计学意义(P<0．05);而且HBO组放射治疗副反应及并发症亦明显减少。结论HBO治疗后立即放射治疗是提高宫颈癌放射治疗疗效的有效途径。选择合理的对象和应用时机是提高疗效的关键环节。Objective To explore the clinical value when treating cervical cancer of supplementing radiotherapy with hyperbaric oxygen treatment. Methods Fifty-eight cervical cancer patients were randomly divided into 2 groups： the HBO group （n=28） received radiotherapy combined with hyperbaric oxygen treatment; a control group （n=30） received only radiotherapy. Results The complete response rate （CR） of the HBO group was 75.0% , the partial response rate （PR） was 7.1% ,the effective rate（CR ＋PR） was 92.8%, the total 3 year survival rate was 71.4%, the local recurrence rate was 10.7% , and all of these results were significantly different from the controls （P 〈0.05 ）. Conclusion Hyperbaric oxygen treatment can increase the effectiveness of radiotherapy in the treatment of cervical cancer.

关 键 词：高压氧 宫颈癌 放射治疗 

分 类 号：R737.33[医药卫生—肿瘤]