新辅助化疗治疗宫颈癌31例临床观察  

Neoadjuvant Chemotherapy in the Treatment of Cervical Cancer:Clinical ObServation in 31 Cases

作　　者：吕娟[1] 刘志鹏[1] 范裕如[1] 

机构地区：[1]南京市妇幼保健院,江苏南京210004

出　　处：《实用妇产科杂志》2006年第8期468-471,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的：探讨新辅助化疗在Ⅰb2～Ⅱb期宫颈癌辅助治疗中的临床效果。方法：31例宫颈癌患者。术前采用1～3个疗程的静脉化疗，之后全部行宫颈癌根治术。通过观察患者病灶大小的改变、化疗毒副反应、术中情况、术后病理反应等，评价新辅助化疗在宫颈癌治疗中的作用及安全性。结果：化疗有效率为87．1％，其中5例完全缓解。化疗效果与期别无关，而与病理类型有关，鳞癌的有效率明显高于腺癌（P〈0．05）。化疗毒副反应轻微。所有患者化疗后均进行了广泛性子宫切除术及盆腔淋巴清扫术。结论：宫颈癌新辅助化疗是安全有效的。经过新辅助化疗，使某些局部晚期病例得以切除。Objective：To investigate the clinical effect of neoadjuvant cherrctherapy on cervical cancer in stage Ⅰb2～Ⅱb.Methods：31 patients with cervical cancer were treated with a 1- 3 course of venous chemotherapy,and then underwent radical surgenj in all of them.The effect and safety of chemotherapy in the treatment of cervical cancer were evaluated by the lesion size,toxic side effects,operative status,and pathology. Results： The effective rate of chemotherapy was 87.1% with 5 cases of total complete remission. The therapeutic effect was not associated with clinical staging, but related to histology,the response to chemotherapy in squarrous cell cancer was significantly higher than adenocarcinoma （ P 〈 0.05）. Toxic side effects were weak. After neoadjunct chemotherapy, all of these patients were performed radical hysterectomy and pelvic lymphorectomy. Concluslons： Neoacljuvant chemotherapy of cervical cancer is a safe and effective therapeutic method,some locally advanced patients can be treated by surgery then.

关 键 词：宫颈癌 新辅助化疗 手术治疗 

分 类 号：R737.33[医药卫生—肿瘤] R730.53[医药卫生—临床医学]