盐酸法舒地尔治疗急性脑梗死的临床研究  

A Clinical Study on Treatment of Acute Cerebral Infarction with Hydrochloric Fasudil

作　　者：张琳[1] 王超[2] 董太和[1] 直玉秋[1] 朱柒锦 许冬青[1] 王利宇 

机构地区：[1]北京市顺义区医院神经内科,101300 [2]北京市安贞医院神经内科

出　　处：《实用心脑肺血管病杂志》2006年第5期362-363,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨新型扩血管药盐酸法舒地尔治疗急性脑梗死的效果。方法选择我院2005年1月～12月治疗的急性脑梗死患者165例,随机分为治疗组105例,对照组60例,对照组给予常规治疗,治疗组在此基础上给予盐酸法舒地尔,观察评价两组患者的显效率、有效率、神经功能改善及病残程度的恢复情况等。结果治疗组与对照组疗效间比较差异有显著性意义(u=3.41,P<0.01)。结论法舒地尔能增加病灶侧大脑中动脉和大脑前动脉的血流速度,对于急性脑梗死的治疗,盐酸法舒地尔是一种安全有效的药物。Objective To investigate treatment effects of hydrochloric fasudil, a new type vasodilating drugs, on acute cerebral infarction. Methods A randomized double - blind study was designed to value effects of fasudil on acute cerebral infarction, with routine therapy as placebo - control group. 165 patients were chosen from Jan 2005 to Dec 2005, which were divided into two groups： fasudil group （105 cases） and control group （60 cases）. Excellency, efficacy, improvement of neurological function and restoration of invalidity were observed. Results In fasudil group, Excellency, efficacy, improvement of neurological function and restoration of invalidity were elevated markedly compared with those in placebo - control group （ P 〈 0. 01 ）. Conclusion Fasudil is able to increase blood flow rate in the focal middle and anterior cerebral artery; with regard to therapy of acute cerebral infarction, fasudil is a kind of safe and effective medicine.

关 键 词：脑梗死 法舒地尔 血流速度 

分 类 号：R743.33[医药卫生—神经病学与精神病学]