血清ConA非结合型GPDA检测及其临床应用  

Detection of Serum ConA-non-reactive-glycoforms of glycylproline depeptidyl aminopeptidase and its clinical application

作　　者：魏群[1] 黄介飞[1] 张弘[1] 倪润洲[1] 江枫[1] 肖明兵[1] 李峰[1] 茅美云[1] 

机构地区：[1]南通大学附属医院消化内科,江苏226001

出　　处：《交通医学》2006年第4期392-393,共2页Medical Journal of Communications

摘　　要：目的:建立血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)糖链异质性的检测法。方法:利用伴刀豆素A(ConA)与等量血清孵育法测定血清中ConA非结合型GPDA。结果:正常人血清中ConA非结合型GPDA为12.1￣42.1U/L,原发性肝癌时明显升高。结论:本法简便,灵敏度高,有助于肝癌的早期诊断。Objective：To establish the detection of serum glycoforms of glycylproline depeptidyl aminopeptidase（GPDA） sugar - chain heterogeneities. Methods：To utilize ConA and equivalence serum incubation to detect serum ConA-non-reactive-GPDA（GPDA- N-C）.Results：The serum GPDA-N-C level is 12.1-42.1U/L in normal subjects, and is significantly higher in patients with primary hepatic carcinoma.Conclusion： This method is both simple and sensitive.GPDA-N-C is useful to the earlier period diagnosis of PHC.

关 键 词：原发性肝癌 甘氨酰脯氨酸二肽氨基肽酶 伴刀豆素A非结合型GPDA 

分 类 号：R730.43[医药卫生—肿瘤]