乙胺丁醇中毒性视神经病变21例临床分析  

Twenty-one cases clinical analysis of changes in toxic optic nerves by ethambutol

作　　者：陈进波[1] 丘少杰[1] 

机构地区：[1]广东省惠州市中心医院眼科,惠州516001

出　　处：《中国实用眼科杂志》2006年第8期822-824,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨乙胺丁醇中毒性视神经病变的防治。方法分析21例不同剂量与视功能损害的关系及治疗迟和早的效果。结果日剂量组视力损害:发生时间0.75g组6.1月为最迟,1.5g组2.3月为最早,各组比较P<0.005;下降程度0.75g组0.73为最小,1.5g组0.032为最大,P<0.0025。视野、色觉:0.75g组仍正常,余随日剂量增大损害加重。视功能损害与总剂量关系不大。疗效:10天内开始治疗平均视力达1.15,>20天者0.33,各组比较P<0.02;视野、色觉10天内治疗全部恢复正常,>20天者仅1例恢复正常。结论乙胺丁醇视功能损害与日剂量成正比,小剂量可减少损害.定期检查、监测视功能,一旦发生损害,立即停药治疗挽救视功能。Objective To investigate the prevention and treatment for changes in toxic optic nerves. Methods Different daily dose and total in 21 patients with their lesion in optic function in degree,and treatment in time or not were analysed. Results Visual acuity injury in daily does group：occurring time,0.75 at 6.1 months, 1.5 at 2.3 months; 0.75 at 0.73 in degree, 1.5 at 0.032 in degree. There were significant differences （P 〈0.005 and P〈0.0025）.Visual field and color sense：0.75 was still normal,in other groups as daily does increased, more severe was injury, which wasn＇t related to total does.Curative effect：visual recovered to 1.15 in 10 days treatmeng with average 0.33 more than 20 days（P〈0.02）.Lesion in visual field and color sense returned to normal in l 0 days,only one patient（1 eyes）was normal in more than 20 days. Conclusion Injury of visual function by ethambutol is proportionate to daily does with small does may reduce lesion.Once lesion occurs, adminstration will be stopped and with treatment immediately through periodic examination or detection.

关 键 词：乙胺丁醇 中毒 视神经病变 视功能 

分 类 号：R774.6[医药卫生—眼科] R978.3[医药卫生—临床医学]