溃疡性结肠炎患者结肠黏膜肝细胞生长因子的表达意义  

Expression and signification of hepatocyte growth factor and its receptor c-Met in colonic mucosa from patients with ulcerative colitis

作　　者：陈凡[1] 林琳[2] 张红杰[2] 王涛[1] 杨希宁[1] 

机构地区：[1]安徽马鞍山市中心医院消化内科,243000 [2]南京医科大学第一附属医院消化科

出　　处：《中华消化内镜杂志》2006年第4期272-274,共3页Chinese Journal of Digestive Endoscopy

基　　金：江苏省自然科学基金资助(BK2004158); 江苏省"135工程"重点人才项目基金资助[苏卫科教(2003)19号]

摘　　要：目的探讨肝细胞生长因子(HGF)及其受体 c-Met 在活动性和非活动性溃疡性结肠炎(UC)患者结肠黏膜组织的表达意义。方法采用免疫组化 SABC 法检测活动性和非活动性 UC 患者以及对照组肠镜活检组织中 HGF、c-Met 表达;SP 法检测增殖细胞核抗原(PCNA)表达。结果对照组、活动性 UC 组、非活动性 UC 组 HGF 阳性表达率分别为25%、88%、100%;c-Met 阳性表达率分别为25%、92%、100%;组间比较有显著性差异,P 均<0.05;HGF、c-Met 在 UC 结肠黏膜表达与 PCNA过表达正相关(r 分别为0.648、0.645,P 均<0.05)。结论 HGF 及其受体 c-Met 可能在 UC 结肠炎症黏膜修复中起作用。Objective To study on the expression of hepatocyte growth factor（HGF） and its receptor c-Met in colonic mucosa of patients with active or inactive ulcerative colitis so as to explore the clinical significance of HGF and c-Met expression in the repairing process of inflamed mucosa in ulcerative colitis. Methods SABC immunohistochemical method was used to examine HGF and c-Met expression and SP immunohistochemical method to examine the expression of proliferation cell nuclear antigen （PCNA） in colon mucosal specimens of active and inactive ulcerative colitis groups or from control group. Results In control group, active and inactive ulcerative colitis groups, the positive rates of expression of HGF were 25%, 88% , 100% , and of c-Met were 25%, 92% , 100% , respectively; significant differences were found among these three groups. In addition, the expression of HGF, c-Met in ulcerative colitis was significantly correlated with the over expression of PCNA（ r = 0. 648, P 〈 0. 05 ; r = 0. 645 ,P 〈 0. 05 respectively）. Conclusion HGF and its receptor c-Met may be involved in the repairing of colonic inflammatory mucosa in ulcerative colitis.

关 键 词：结肠炎 溃疡性 肝细胞生长因子 受体 c-Met 增殖细胞核抗原 

分 类 号：R574.62[医药卫生—消化系统]