Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury  

作　　者：Takayuki Kogure Yoshiyuki Ueno Noriatsu Kanno Koji Fukushima Yoko Yamagiwa Futoshi Nagasaki Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Masashi Ninomiya Tooru Shimosegawa 

机构地区：[1]Division of Gastroenterology Tohoku University Graduate School of Medicine,1-1 Seiryo,Aobaku,Sendai 980-8574,Japan

出　　处：《World Journal of Gastroenterology》2006年第29期4757-4760,共4页世界胃肠病学杂志（英文版）

摘　　要：A 29-year-old nurse with a hepatitis C virus （HCV） infection caused by needle-stick injury was treated with interferon-beta starting about one year after the onset of acute hepatitis. The patient developed acute hepatitis C with symptoms of general fatigues, jaundice, and ascites 4 wk after the needle-stick injury. When these symptoms were presented, the patient was pregnant by artificial insemination. She hoped to continue her pregnancy. After delivery, biochemical liver enzyme returned to normal levels. Nevertheless, HCV RNA was positive and the pathological finding indicated a progression to chronicity. The genotype was lb with low viral load. Daily intravenous injection of interferon-beta at the dosage of six million units was started and continued for eight weeks. HCV was eradicated without severe adverse effects. In acute hepatitis C, delaying therapy is considered to reduce the efficacy but interferon-beta therapy is one of the useful treatments for hepatitis C infection in chronic phase.有感染由针棍子损害引起了的一个丙肝病毒(HCV ) 的一个 29 岁的护士与在尖锐肝炎的发作以后开始大约一年的干扰素贝它被对待。有一般疲劳，黄疸，和腹水的症状的耐心的发达尖锐丙肝在针棍子损害以后的 4 wk。当这些症状被介绍时，病人由人工授精是怀孕的。她希望了继续她的怀孕。在交货以后，生物化学的肝酶回到了正常层次。不过， HCV RNA 是积极的，病理学的发现显示了前进到慢性。遗传型是有低病毒的负担的 1b。在 600 万个单位的剂量的干扰素贝它的每日的静脉注射被开始并且继续八个星期。没有严重不利效果， HCV 被根除。在尖锐丙肝，推迟治疗被认为减少功效，但是干扰素贝它治疗是为在长期的阶段的丙肝感染的有用治疗之一。

关 键 词：Hepatitis C virus Acute hepatitis INTERFERON-BETA Needle stick injury 

分 类 号：R512.63[医药卫生—内科学]