INTERFERON-BETA

作品数：9被引量：20H指数：2
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Bifidobacterium longum subsp.infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice
《Food Science and Human Wellness》2025年第1期345-360,共16页Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu RPaul Ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen 
funded by the National Key R&D Program of China(2021YFD2100700);National Natural Science Foundation of China(32021005);111 project(BP0719028);Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
Bifidobacterium longum subsp.infantis is a commensal bacterium that predominates in the infant gut,playing a critical role in both preventing foreign infections and facilitating immune development.This study aimed to ...
关键词：Bifidobacterium longum subsp.infantis Intestinal barrier interferon-beta(IFN-β)secretion Age dependence 
Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection
《Virologica Sinica》2023年第1期23-33,共11页Weijie Chen Yukun Li Xiuling Yu Zhenwei Wang Wenbiao Wang Menglan Rao Yongkui Li Zhen Luo Qiwei Zhang Jinbiao Liu Jianguo Wu 
supported by the National Natural Science Foundation of China(81730061,81802008);the Guangdong Basic and Applied Basic Research Foundation(2021A1515011272).
Zika virus(ZIKV)evolves non-structural proteins to evade immune response and ensure efficient replication in the host cells.Cholesterol metabolic enzyme 7-dehydrocholesterol reductase(DHCR7)was recently reported to im...
关键词：7-Dehydrocholesterol reductase(DHCR7) Interferon regulatory factor 3(IRF3) Interferon-beta(IFN-β) Non-structural protein 4B(NS4B) TANK-Binding kinase 1(TBK1) Zika virus(ZIKV) 
Interferon-beta inhibits human glioma stem cell growth by modulating immune response and cell cycle related signaling pathways
《Cell Regeneration》2022年第1期212-226,共15页Xin-Xin Han Shengkai Jin Li-Ming Yu Min Wang Xin-Yu Hu Dai-Yu Hu Jie Ren Meng-Han Zhang Wei Huang Jia-Jia Deng Qing-Qing Chen Zhengliang Gao Hua He Chunhui Cai 
This work was supported by funds from the National Natural Science Foundation of China[31600819 to CCH,81901031 to HXX,32070862 and 31571058 to GZL];the Shanghai Municipal Population and Family Planning Commission[20174Y0216 to CCH];the Natural Science Foundation of Shanghai[19ZR1445400 to HXX];the National Key R&D Program of China[2019YFA0110300];the Shanghai Easter Scholar[8101219003 to GZL].
Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential.The main reason is that malignant glioma holds key cluster cells,glioma stem cells(GSCs).GSCs contribute to tum...
关键词：Glioma stem cells IFN-Β Neural stem cell Cell cycle Immune response 
Neddylation is required for herpes simplex virus type I （HSV- 1）-induced early phase interferon-beta production被引量：7
《Cellular & Molecular Immunology》2016年第5期577-583,共7页Xueying Zhang Zhenjie Ye Yujun Pei Guihua Qiu Qingyang Wang Yunlu Xu Beifen Shen Jiyan Zhang 
Type I interferons such as interferon-beta （IFN-β） play essential roles in the host innate immune response to herpes simplex virus type I （HSV-1） infection. The transcription of type I interferon genes is control...
关键词：innate immunity HSV-1 IFN-Β NF-βB IRF3 
Natural interferon-beta treatment for patients with chronic hepatitis C in Japan
《World Journal of Hepatology》2015年第8期1125-1132,共8页Reina Sasaki Tatsuo Kanda Shingo Nakamoto Yuki Haga Masato Nakamura Shin Yasui Xia Jiang Shuang Wu Makoto Arai Osamu Yokosuka 
Chronic hepatitis C virus(HCV) infection can cause liver cirrhosis and hepatocellular carcinoma(HCC). Several studies have demonstrated that the eradication of HCV reduces the occurrence of HCC. In Japan, as many peop...
关键词：HEPATOCELLULAR carcinoma HEPATITIS C VIRUS INTERFERON-BETA INTERFERON resistance RIBAVIRIN 
Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound
《World Journal of Biological Chemistry》2013年第2期18-29,共12页Zaifang Yu Jarrod D Predina Guanjun Cheng 
Supported by NCI PO1 CA 66726
AIM:To explore the possibility that nucleotide oligomerization domain 1(NOD1) pathway involved in refractoriness of interferon-β signaling in mouse respiratory epithelial cells induced by the anticancer xanthone comp...
关键词：INNATE immunity Interferon REFRACTORINESS XANTHONE BRONCHIAL EPITHELIUM 
Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury
《World Journal of Gastroenterology》2006年第29期4757-4760,共4页Takayuki Kogure Yoshiyuki Ueno Noriatsu Kanno Koji Fukushima Yoko Yamagiwa Futoshi Nagasaki Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Masashi Ninomiya Tooru Shimosegawa 
A 29-year-old nurse with a hepatitis C virus （HCV） infection caused by needle-stick injury was treated with interferon-beta starting about one year after the onset of acute hepatitis. The patient developed acute hep...
关键词：Hepatitis C virus Acute hepatitis INTERFERON-BETA Needle stick injury 
Is interferon-beta an alternative treatment for chronic hepatitis C?
《World Journal of Gastroenterology》2006年第17期2730-2736,共7页Ricardo Moreno-Otero María Trapero-Marugán Elena Gómez-Domínguez Luisa García-Buey JoséA Moreno-Monteagudo 
Supported by grants C 03/02 from Institute de Salud Carlos III and SAF 2001-1414 from Ministerio de Ciencia y Tecnologia
The treatment of chronic hepatitis C （CHC） is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-α （IFNα） plus ribavirin. Althou...
关键词：Hepatitis C Hepatitis C virus Interferon beta RIBAVIRIN 
Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C被引量：13
《World Journal of Gastroenterology》2004年第5期733-736,共4页Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki 
AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was assoc...
关键词：Adult Antiviral Agents dosage Drug Resistance  Viral Female HEPACIVIRUS Hepatitis C  Chronic Humans In Vitro INTERFERON-BETA Leukocytes  Mononuclear Male Middle Aged Predictive Value of Tests RNA  Viral 
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