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作品数：292被引量：1214H指数：16
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Emerging role of microglia in the developing dopaminergic system:Perturbation by early life stress
《Neural Regeneration Research》2026年第1期126-140,共15页Kaijie She Naijun Yuan Minyi Huang Wenjun Zhu Manshi Tang Qingyu Ma Jiaxu Chen 
supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC);the National Key R&D Program of China,No.2023YFE0209500(to JC);China Postdoctoral Science Foundation,No.2023M732380(to NY);Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC);National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM);Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily inv...
关键词：Chinese herbal drugs dopamine early life stress epigenetics gut-brain axis hypothalamo–pituitary–adrenal axis innate immune memory MICROGLIA neuroinflammation Parkinson disease PHAGOCYTOSIS REWARD 
β‑Hydroxybutyrate‑induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy
《Journal of Animal Science and Biotechnology》2025年第2期653-667,共15页Yihui Huo Taiyu Shen Tianyin Feng Moli Li Wanli Zhao Juan JLoor Ben Aernouts Androniki Psifidi Chuang Xu 
supported by the National Natural Science Foundation of China(32125038);the National Key R&B Program of China(2023YFD1801100);China Agriculture Research System(CARS-36).
Background In perinatal dairy cows,ketosis is a prevalent metabolic disorder that lowers milk output and per-formance.Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood k...
关键词：AUTOPHAGY Bovine mammary gland Inflammation Mitochondria DNA 
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
《Research》2025年第1期149-163,共15页Liqiu Wang Mengqiu Li Guangyu Lian Shuai Yang Yaoxing Wu Jun Cui 
supported by the National Natural Science Foundation of China(32300730);the Guangdong Science and Technology Department(2023B12120600280);the National Postdoctoral Program for Innovative Talents of China(BX20220365);the China Postdoctoral Science Foundation(2023M734057);the Fundamental Research Funds for the Central Universities(23yxqntd001).
As a key executioner of pyroptosis,Gasdermin D(GSDMD)plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases.So far,the understanding of the mechan...
关键词：USP excessive innate immun host defense innate immune responses ubiquitin specific peptidase selective autophagy 
Unconscious and Conscious Gaze-Triggered Attentional Orienting:Distinguishing Innate and Acquired Components of Social Attention in Children and Adults with Autistic Traits and Autism Spectrum Disorders
《Research》2025年第1期634-646,共13页Fang Yang Junbin Tian Peijun Yuan Chunyan Liu Xinyuan Zhang Li Yang Yi Jiang 
supported by the Ministry of Science and Technology of China(2021ZD0203800 and 2021ZD0204200);the National Natural Science Foundation of China(31830037);the Key Research and Development Program of Guangdong(2023B0303010004);the Interdisciplinary Innovation Team of the Chinese Academy of Sciences(JCTD-2021-06);Fundamental Research Funds for the Central Universities.
Typically developing(TD)individuals can readily orient attention according to others'eye-gaze direction,an ability known as social attention,which involves both innate and acquired components.To distinguish between th...
关键词：unconscious gaze critical flicker fusion technique social attention orient attention conscious gaze attentional orienting gaze cues social attentionwhich 
Systematic analysis of innate immune-related genes in the silkworm:Application to antiviral research
《Insect Science》2025年第1期151-171,共21页Junming Xia Ruoxuan Peng Shigang Fei Mian Muhammad Awais Wenxuan Lai Yigui Huang Hailin Wu Yue Yu Lingying Liang Luc Swevers Jingchen Sun Min Feng 
supported by the National Natural Science Foundation of China(32372945);Guangzhou Science and Technology Plan(202201010369);Natural Science Foundation of Guangdong Basic and Applied Basic Research Fund(2022A1515012657);South China Agricultural University high-level talent launch project.
The silkworm,a crucial model organism of the Lepidoptera,offers an excellent platform for investigating the molecular mechanisms underlying the innate immune response of insects toward pathogens.Over the years,researc...
关键词：antiviral defense BMNPV Bombyx mori innate immunity SilkDB 3.0 
Unveiling the dynamic role of innate and adaptive immune cells in COPD pathogenesis induced by cigarette smoke
《Life Research》2024年第4期29-41,共13页Dur E Maknoon Razia Syed Sib Tul Hassan Shah Tabish Faheem 
Chronic obstructive pulmonary disease(COPD)is a multifaceted syndrome characterized by a dysregulated inflammatory cascade within the respiratory system,primarily triggered by exposure to harmful particles and gases,n...
关键词：chronic obstructive pulmonary disease innate immunity adaptive immunity cigarette smoke inflammation oxidative stress protease-antiprotease imbalance 
GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response
《Neuroscience Bulletin》2024年第12期1886-1900,共15页Man Yuan Gao Tan Danrui Cai Xue Luo Kejiong Shen Qinqin Deng Xinlan Lei Wen-Bo Zeng Min-Hua Luo Lu Huang Chaoran Ren Yin Shen 
supported by grants from the National Key R&D Program of China(2017YFE0103400);the National Natural Science Foundation of China(81470628 and 82471086).
The looming stimulus-evoked flight response to approaching predators is a defensive behavior in most animals. However, how looming stimuli are detected in the retina and transmitted to the brain remains unclear. Here,...
关键词：scpgRGCs Innate defensive behavior GABA LOOMING Superior colliculus Flight response 
Current progress of virus-mediated gene therapy-where we are and what we need
《感染控制(英文)》2024年第3期8-20,共13页Wei Miao 
Viral vectors are instrumental in gene therapy and vaccination,addressing a spectrum of diseases from genetic disorders to cancer.Despite their promise,their clinical utility is hampered by the propensity to provoke h...
关键词：viral vectors IMMUNOGENICITY gene therapy innate and adaptive immune systems immune evasion strategies 
Phosphorylation of CAX transporters controls Ca^(2+) homeostasi
《Plant Communications》2024年第9期8-11,共4页Jinggeng Zhou Yunxia He Xiangzong Meng 
supported by the National Natural Science Foundation of China(grants 32370291 to J.Z.and 32370313 to X.M.);the Natural Science Foundation of Shanghai(grant 22ZR1446300 to J.Z.).
Plants rely on a sophisticated innate immune system to recognize and defend against invading pathogens.The first line of plant innate immunity,called pattern-triggered immunity(PTI),is initiated upon detection of path...
关键词：IMMUNITY pattern INNATE 
Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node被引量：1
《Cellular & Molecular Immunology》2024年第9期999-1007,共9页Carolina R.Melo-Silva Luis J.Sigal 
The interstitial fluids in tissues are constantly drained into the lymph nodes(LNs)as lymph through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics.LNs are strategically positioned a...
关键词：Virus infection lymph borne virus lymph node virus control innate immunity adaptive immunity dendritic cells Langerhans cells macrophages inflammatory monocytes natural killer cells CD8+T-cells 
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