Toll样受体与免疫排斥  

TLR and Rejection

作　　者：张临友[1] 修殿辉[1] 杨宝峰[2] 

机构地区：[1]哈尔滨医科大学附属第二医院胸外科,150086 [2]哈尔滨医科大学

出　　处：《国际免疫学杂志》2006年第4期209-213,共5页International Journal of Immunology

摘　　要：随着Toll样受体(TLR)的发现,固有免疫应答如何调控适应性免疫应答已成为研究的热点。许多研究结果表明,微生物分子触发的病原体相关分子模式(PAMP)和TLR可以被内源性配体激活,并在哺乳动物体内表达。这些“危险信号”在器官移植后对于缺血再灌注损伤的发生、移植器官功能的影响及存活时间都起着重要的作用。Recently, with the discovery of the Toll-like receptors （TLR）, the role of innate immune responses in the control of adaptive immunity has become a new area of interest. Emerging evidence suggests that responding to pathogen-associated molecular patterns of microorganisms, TLR can be activated by endogenous ligands, and expressed by mammalian cells. These＇danger signals＇may participate in ischemia-reperfusion-related organ damage and subsequently influence the function and survival of transplanted grafts.

关 键 词：TLRS 免疫排斥 

分 类 号：R392[医药卫生—免疫学]