国产吉西他滨联合顺铂治疗复发性乳腺癌的临床观察  

Clinical observation of gemcitabine plus cisplatin in the treatment for 36 cases of recurrent breast cancer

作　　者：庞慧[1] 蔡莉[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内四科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2006年第4期278-279,共2页Practical Oncology Journal

摘　　要：目的观察国产吉西他滨(GEM)联合顺铂(DDP)治疗复发性乳腺癌的疗效及毒副作用。方法采用GEM与DDP联合治疗复发性乳腺癌患者36例。化疗剂量:GEM1000mgm2d1、8静滴;DDP25mgm2d1～3静滴;21天为一个周期,至少治疗两周期。结果CR3例,PR17例,SD10例,PD6例,总有效率(CR+PR)55.55%。毒副作用主要为骨髓抑制,恶心、呕吐等。白细胞及血小板减少的发生率分别为61.11%和58.33%,恶心、呕吐发生率为61.11%。结论GEM联合DDP治疗复发性乳腺癌疗效好,毒副作用可耐受,有较好的临床应用价值。Objective To evaluate the efficacy and toxicity of combined chemotherapy with gemcitabine （GEM） plus cisplatin （DDP） in the treatment of recurrent breast cancer. Methods Thirty- six patients with recurrent breast cancer were enrolled for this study. GEM were administered 1 000 mg/m^2 on day 1,8 ; DDP 25 mg/m^2 on day 1 ~ 3, which was recycled every 3 weeks and with at least 2 cycles. Results Among 36 patients, 3 patients achieved completed response, 17 patients achieved partial response, 10 patients achieved stable disease and 6 patients achieved progressive disease. The overall response rate is 55.55 %. The main tox- icities were myelosuppression, nausea and vomiting. Leukopenia accounted for 61.11%, thrombocytopenia accounted for 58.33 %, nausea and vomiting accounted for 61.11%. Conclusion The schedule of gemcitabine plus cisplatin in the treatment for 36 cases of recurrent breast cancer has good clinical efficacy and tolerability, the regimen could be quite clinically valuable.

关 键 词：吉西他滨 顺铂 联合化疗 复发性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]